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Graduate Theses and Dissertations

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https://hdl.handle.net/10388/381
This collections holds all University of Saskatchewan graduate level electronic theses and dissertations (ETDs) published since 2005. More than 700 print theses published before 2005 have been digitized and added to the collection as well.

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Browsing Graduate Theses and Dissertations by Subject "- Osteoporosis - Diabetes - Bone density - Fragility fractures - Survival analysis - Cox proportional hazards model - Hazard ratio - Risk factors - Age - Sex - Hyperlipidemia - Hypertension - Smoking - Korea - Asian population - Retrospective cohort - Population-based study - Time-to-event analysis - Kaplan-Meier analysis - Epidemiology - Public health - Chronic disease - Comorbidity"

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    Examination of diabetes as a risk factor for osteoporosis among older adults in Korea: A population-based cohort study
    (2023-11-02) Das, Tanmoy; Lim, Hyun June; Balbuena, Lloyd Cenon; Mondal, Prosanta kumar; Janzen, Bonnie
    With population aging worldwide, the prevalence of diabetes has significantly risen, leading to various complications. Recent evidence suggests there could be potential associations between diabetes as osteoporosis risk. This thesis aimed to examine whether diabetes represents an independent risk factor for osteoporosis onset in Korean adults aged 50 years and older. The analysis utilized longitudinal data from the Korean National Health Panel Survey from 2008-2018, following 7304 participants aged 50+ years at baseline. Among them, a total of, 1616 individuals with diabetes and 5688 without diabetes were followed for up to 11 years to identify new clinically diagnosed osteoporotic events, including osteoporosis or osteoporotic fractures, based on Korean Standard Disease Classification codes. Kaplan-Meier curves displayed visual comparison of survival over time between diabetes groups and other different risk factors for osteoporosis events, and Cox proportional hazards models calculated adjusted hazard ratios (HRs) of different risk factors. Over the study period, 794 new osteoporotic events were documented. Diabetes status did not significantly impact osteoporosis risk in multivariate analysis. Older age (70+ years) (vs. 50-60 years) (HR=10.32, 95% CI: 3.25–32.80) and female sex (vs. male) (HR=9.05, 95% CI: 5.32–15.40) emerged as key factors independently associated with greater osteoporosis hazards. Unexpectedly, people with hypertension (vs no hypertension) and previous smokers (vs non-smokers) had lower osteoporosis risk. There was a significant interaction of sex and age, with 60–70-year-old females having higher risk than their male counterparts. In summary, while diabetes itself was not implicated as an independent predictor, this thesis identified critical demographic and clinical factors for osteoporosis onset in Korean adults aged 50+ years. These findings can guide screening initiatives and future research on underlying mechanisms.