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College of Dentistry

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    Digital ulcers associated with scleroderma: a major unmet medical need
    (Wound Repair and Regeneration, 2024-09) Naik, Angha; Stratton, Richard; Leask, Andrew
    Scleroderma or systemic sclerosis (SSc) associated digital ischemic complications, such as digital ulcers (SSc-DUs), appear relatively early during the disease course and are a major burden with substantial deterioration of quality of life. Expert rheumatologist and wound specialists have defined a DU; however, international application of the definition is still disorganized. Appearance of SSc-DUs is secondary to the onset of Raynaud’s phenomenon (RP) and as a consequence, recommended first-line of treatment mainly includes vasodilators; however, many DUs are refractory to this treatment. Despite important practical issues, such as a lack of well characterized SSc-wound healing animal model, significant efforts are needed to mechanistically understand the pathogenesis of SSc-DUs for developing clinically targetable disease modifying therapies.
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    Influence of sex, age and ethnicity on the facial temperature
    (Springer, 2024-08-13) Barbosa, Jussara da Silva; de Melo, Niebla Bezerra; Firmino, Ramon Targino; Ferreira, José Eraldo Viana; Amorim, Ana Marly Araújo Maia; de Melo, Daniela Pita; Bento, Patrícia Meira
    Infrared thermography (IRT) allows the acquisition of a thermal profile of an anatomical region of interest from a physiological perspective. For a real-time, dynamic and physiological analysis of the microcirculation, IRT is now being employed to analyze skin temperature based on the infrared radiation emitted by the human body, and may be used as an adjuvant in the diagnosis of disease and to monitor therapeutic procedures. The aim of this study was to evaluate the influence of age, sex, ethnicity and body mass index (BMI) on temperature in the facial macro and microregions of healthy subjects.