Browsing by Author "Haddadi, Azita"
Now showing items 1-9 of 9
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CHARACTERIZING THE SIGNALING AND TUMOR SUPPRESSOR ROLE OF FRK IN BREAST CANCER
Ogunbolude, Yetunde 1986- (2018-09-17)The human Fyn-related kinase (FRK) is a non-receptor tyrosine kinase known to have tumor suppressor activity in breast cancer cells. FRK expression is mostly absent in mesenchymal breast cancer cells but present in epithelial ... -
DESIGN AND DEVELOPMENT OF CD205 TARGETED PLGA NANOPARTICLES AND EVALUATION OF ANTIGEN SPECIFIC IMMUNE RESPONSES
Jahan, Sheikh Tasnim 1984- (2017-05-26)Stimulation of a patient’s immune system to fight cancer is the underlying mechanism of immunotherapy. Cancer immunotherapy manipulates the dendritic cells (DCs) to identify the non-self present in the immunosuppressive ... -
DEVELOPMENT OF PEPTIDE-MODIFIED GEMINI SURFACTANTS AS NON-VIRAL GENE DELIVERY SYSTEM.
Al-Dulaymi, Mays Aiyed Mohan 1989- (2018-08-22)Gene therapy is a promising therapeutic approach for the treatment of inherited and acquired genetic disorders. Gemini surfactants are an emerging class of cationic lipids that has shown promising results in delivering ... -
INVESTIGATION OF LIGAND SIZE ON TARGETED PLGA NANOPARTICLES FOR HER2 BREAST CANCER: TRASTUZUMAB AND ITS ScFv ANTI-HER2 ANTIBODY
Zagzoog, Ayat H 1990-; 0000-0002-3866-3972 (2018-06-21)This research focuses on assessing the effect of various formulation parameters on targeting human epidermal growth factor receptor-2 (HER2) specifically in breast cancer. Poly (D, L-lactide-co-glycolide) (PLGA) polymer, ... -
INVESTIGATIONS INTO RARE COORDINATION ENVIRONMENTS OF AL, P AND PD SPECIES: SYNTHESIS AND APPLICATIONS
Wu, Shih-Chang (2015-10-23)This research work includes three parts, with the first section describing the synthesis and applications of neutral 3-coordinate aluminum complexes. As demonstrated in this part, aluminum complexes in a 3-coordinate ... -
PHYSIOCHEMICAL STABILITY AND MASS SPECTROMETRIC ANALYSIS OF GEMINI SURFACTANT-BASED LIPOPLEXES
Mohammed Saeid, Waleed (2012-09-14)Cationic lipids have been comprehensively studied as non-viral vectors for gene therapy, focusing on improving the gene transfer efficiency and the safety profile. However, clinical applications of cationic lipid/DNA ... -
PROTEINS pV AND pVIII ENCODED BY BOVINE ADENOVIRUS-3 ARE POTENTIAL VIRAL SUPPRESSORS OF THE INTERFERON RESPONSE
Hao, Mingjie (2017-09-19)Bovine adenovirus 3 (BAdV-3), which belongs to the Mastadenovirus genus, is a non-enveloped virus with an icosahedral capsid of 75 nm diameter, which wraps a double-stranded linear DNA genome with size of 34,446 base pairs ... -
Strained Ferrocenophanes Bridged by Silicon for New Metallopolymers
Esteban Flores, Jose 1993-; 0000-0003-3083-3882 (2017-09-21)In recent years, the Müller group has developed a route to strained ferrocenophanes (FCPs) with planar chirality. Alkyl groups are usually incorporated into the ferrocene moiety to increase the solubility of the resulting ... -
Targeted chemotherapy: Trastuzumab tailored Docetaxel loaded PLGA nanoaparticles for HER2 positive breast cancer
Sadat, Sams 1984- (2015-08-17)This study was designed to explore the rationale of using trastuzumab (TmAb) tailored docetaxel (Doc) loaded poly-D, L-lactide-co-glycolide (PLGA) nanoparticles (NPs) to target the human epidermal receptor-2 (HER2) receptors ...