Browsing by Author "Ianowski, Juan"
Now showing items 1-12 of 12
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Abnormal electrophysiological properties in sensory neurons from a swine model of cystic fibrosis
Givzad, Naseem (2020-09-11)Cystic fibrosis (CF) results from dysfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. CF has traditionally been considered a pediatric disease, but the median predicted survival age in ... -
Bent Laue X-ray Beam Expander
Martinson, Mercedes 1982- (2017-02-10)Synchrotron imaging beamlines around the world all suffer from a similar limitation, namely a beam that is smaller in the vertical direction than the horizontal. This can produce a beam that is so small in the vertical ... -
BRONCHOPROTECTION PROVIDED BY LONG-ACTING MUSCARINIC ANTAGONISTS AND ULTRA LONG-ACTING β2 AGONISTS AGAINST METHACHOLINE-INDUCED BRONCHOCONSTRICTION IN MILD ASTHMATICS
Blais, Christianne M 1993- (2017-08-21)Background: Although asthma treatments are extensively studied for their physiological effects in animal models and their safety and efficacy in humans, their effects on standard testing methods and their physiological ... -
Effects of heme oxygenase system on inflammation, oxidative stress, insulin signaling and tissue injury in liver, heart, kidney and pancreas in obese, diabetic and hypertensive rats
Mishra, Manish 1980- (2017-10-31)Tissue injury and metabolic dysfunction are salient features of obesity, diabetes, and hypertension. Inflammation and oxidative stress are considered key players behind this altered tissue homeostasis that drastically ... -
Examining the Roles of Thalamocortical and Frontoparietal Circuitry for Working Memory in the Rat
Scott, Gavin Alexander 1988-; 0000-0001-9476-5060 (2019-12-04)Working memory (WM) is the cognitive capacity for short-term maintenance and manipulation of stimuli and goals for the purpose of guiding behaviour. Research in primates has indicated that WM relies on a large network ... -
INVESTIGATIONS OF WATERBORNE METAL INTERACTIONS IN THE GILLS OF RAINBOW TROUT USING SYNCHROTRON-BASED TECHNIQUES
Saibu, Yusuf Olayiwola 1989- (2017-02-27)Most of our current understanding of metal toxicity in aquatic organisms has been based on single metal toxicity. However, metals do not exist singly in the aquatic environment, but rather as mixtures. As mixtures, they ... -
Linking new genes to an odontogenesis TP63-mediated gene regulatory network that is peripheral to jaw morphogenesis
Rostampour, Nasim 1988-; 0000-0002-6240-7012 (2018-02-27)Despite that teeth and jawbones can develop and evolve independently of each other, the genetic processes that independently regulate cranial and dental morphogenesis remain unclear. Previous microarray screens indicated ... -
Modulation of the endocannabinoid system in Genetic Absence Epilepsy Rats from Strasbourg: New avenues for treatment of absence seizures and behavioural comorbidities.
Roebuck, Andrew J; 0000-0002-3008-8387 (2021-01-15)Current treatments for Absence Epilepsy (AE) are insufficient and do not adequately manage seizures and comorbidities in most patients. With the recent legalization of cannabis in Canada, interest in its use for the treatment ... -
Plasma factors, antibiotic therapy, and sputum bacteria associated with alteration of circulating neutrophils in individuals with cystic fibrosis
Wright, Nathan D (2021-01-15)Cystic fibrosis (CF) is a genetic disease with pathology highly focused on pulmonary complications. Infection and colonisation of CF airways by well established pathogens (e.g., Pseudomonas aeruginosa, Staphylococcus aureus) ... -
RAGE-DEPENDENT SENSITIZATION OF THORACIC SENSORY NEURONS DURING INFLAMMATORY CONDITIONS
G Baskaran, Manoj Nair 1984- (2016-12-19)Various airway inflammatory diseases progress as a result of chronic inflammation, specifically neurogenic inflammation. One factor known to be involved in this is RAGE. This work has established RAGE as a key mediator in ... -
Renewed perspective on efficacy and safety of inhaled muscarinic antagonists as asthma management therapies
Cropper, Kayla J (2021-09-15)Background: Although muscarinic antagonists are currently used to treat asthma, there remain various characteristics that have yet to be fully elucidated. The other major class of bronchodilators, beta 2-agonists, have ... -
THE EFFECTS OF DEGRADING PERINEURONAL NETS IN THE MEDIAL PREFRONTAL AND POSTERIOR PARIETAL CORTICES ON THE SPATIAL WORKING MEMORY OF RATS
Anderson, Michael David 1995-; 0000-0002-3872-8406 (2019-09-10)Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround subsets of neurons in the central nervous system (CNS). They help in maintaining a stable excitatory-inhibitory balance in the brain, ...