Browsing by Author "Kalynchuk, Lisa E."
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Aberrant structural and functional plasticity in the adult hippocampus of amygdala kindled rats
Fournier, Neil M. (2009)Amygdala kindling is commonly used to study the neural mechanisms of temporal lobe epilepsy and its behavioral consequences. The repetitive seizure activity that occurs during kindling is thought to induce an extensive ... -
Antidepressant-Like Effects of Ketamine on Fear Conditioning and Extinction
Kulyk, Brian D. 1990-; 0000-0003-3936-0225 (2017-01-05)The experience of chronic stress plays an important role in the pathogenesis of major depressive disorder. Prolonged stress induces a state of chronically elevated glucocorticoid exposure in the brain, which is neurotoxic ... -
Assessing the role of the hippocampus in amygdala kindled fear : an analysis of environmental habituation
Andersen, Devon Rose (2007-09-14)Amygdala kindling is commonly used to study the mechanisms involved in epileptogenesis, with long-term amygdala kindling providing a useful model of the behavioural disturbances— such as heightened anxiety— that can occur ... -
Conditioning of interictal behaviours, but not ictal behaviours, seizures, or afterdischarge threshold, by kindling of the amygdala in rats
Wagner, Jason P (2007-02-05)Repeated focal electrical stimulation of the brain results in kindling, the development of generalized seizures that progress in length and severity as more seizures are elicited. Barnes et al. (2001) paired one context ... -
Examining reelin expression and neural plasticity in animal models of depression
Lussier, April (2012-06-25)Stress is an important risk factor for the development of depression, but little is known about the neurobiological mechanisms by which stress might promote depressive symptomatology. The hippocampus and amygdala are ... -
Fear Learning as a Component of a Depressive Phenotype in Rodents
Marks, Wendie (2014-06-23)Depression is a complex psychiatric illness that affects a large proportion of the population. Many researchers make use of preclinical animal models to study the behavioural and neurobiological characteristics of this ... -
P38(MAPK) negatively regulates monoamine oxidase-A activity as well as its sensitivity to Ca2+
Cao, Xia (2007)Monoamine oxidase (MAO) is a mitochondrial deaminating enzyme that exists as two isoforms, MAO-A and -B. The MAO-mediated reaction generates hydrogen peroxide (H2O2) as a normal by-product. Dysregulation of MAO has been ... -
Prenatal PolyI:C induced schizophrenia-like cognitive inflexibilities in the male, but not female, rat adult offspring
Zhang, Ying (2011-07)Executive functions are important cognitive processes critical for survival. Damage to the prefrontal cortex impairs executive functions, such as working memory, decision making and set-shifting. Interestingly, patients ...