Browsing by Author "Xiang, Jim"
Now showing items 1-19 of 19
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
Scott, Stuart Alexander (2005-05-18)Promoter hypermethylation mediated gene silencing is a frequent epigenetic finding in many cancers that affects genes known to have important roles in several aspects of cell biology. Hematological malignancies have been ... -
Antitumor effect of the combination of exogenous sphingosine-1-phosphate(S1P), S1P receptor 1(S1PR1) antibody and carboplatin against human breast cancer cells
Xiao, Shujun (Jennifer) 1991-; 0000-0001-9311-7758 (2018-10-02)Breast cancer is the third most common cancer in Canada. Even though the morbidity and mortality rates have reduced in recent years because of early diagnosis and improved treatments, new treatment methods or therapeutic ... -
combining irreversible electroporation (IRE) with TLR3/9 agonists and PD-1 blockade for potent anti-tumor immunity
Babikr, Fatma Ismail (2022-01-13)Cancer is a leading cause of death worldwide, taking nearly 10 million lives each year. CD8+ T cytotoxic lymphocytes (CTLs) play a critical role in human immunity against cancer. Irreversible electroporation (IRE) is a new ... -
Comparison of the Abilities of IL-10- and Retinoic Acid- Differentiated Dendritic Cells to Induce Allergen Tolerance in a Mouse Model of Asthma
Li, Chunyan (2014-11-14)Dendritic cells (DCs) in different compartments can affect tolerance via distinct mechanisms. Thus, retinoid acid (RA) and integrins expressed by CD103+ dendritic cells in the gut play important roles in regional regulatory ... -
THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY
Sokke Umeshappa, Channakeshava (2013-07-29)The goal of this body of research was to elucidate the mechanism by which CD4+ T cells provide help for CD8+ cytotoxic T lymphocyte (CTL) responses in different immunization types. The establishment of diseases, such as ... -
Dendritic cell based cancer vaccines using adenovirally mediated expression of the HER-2/neu gene and apoptotic tumor cells expressing heat shock protein 70
Chan, Tim (2006-08-17)Human Epidermal Growth Factor Receptor 2 (HER-2/neu) is a breast tumor antigen (Ag) commonly overexpressed in 30% of breast cancer cases. Both HER-2/neu-targeted DNA-based and transgene modified dendritic cell (DC)-based ... -
DESIGN AND DEVELOPMENT OF CD205 TARGETED PLGA NANOPARTICLES AND EVALUATION OF ANTIGEN SPECIFIC IMMUNE RESPONSES
Jahan, Sheikh Tasnim 1984- (2017-05-26)Stimulation of a patient’s immune system to fight cancer is the underlying mechanism of immunotherapy. Cancer immunotherapy manipulates the dendritic cells (DCs) to identify the non-self present in the immunosuppressive ... -
The Effect of Transcription Factor Zhangfei/CREBZF on Osteosarcoma Cells and the Mechanisms Responsible
Zhang, Rui (2014-06-18)Osteosarcoma (OS) is the most common primary malignant bone tumour in humans and dogs. Although medicine has made dramatic progress in treating osteosarcoma by surgery, with chemotherapy given before and after surgery, ... -
Enhancing The Efficacy Of DNA Vaccines
Mackenzie-Dyck, Sarah (2014-08-14)Bovine herpesvirus-1 (BoHV-1) causes recurrent respiratory and genital infections in cattle; and predisposes them to lethal secondary bacterial infections. Vaccination is a primary strategy to prevent and reduce the severity ... -
Genetic engineering of a fusion protein possessing anti-tumor Fv and tumor necrosis factor alpha
Yang, Junbao (1999-01-01)In order to target tumor necrosis factor alpha (TNF-α) specifically to tumor cells, we designed, constructed and expressed a recombinant fusion protein single-chain Fv/TNF-α (scFv/TNF-α containing the scFv of B72.3 ... -
HER-2/neu-targeted immunoprevention of breast cancer
Sas, Sheena Emm (2007-03-27)Improvements in the use of traditional breast cancer therapies have improved the overall survival of women with early stage disease. Remarkable advances in research have created a unique opportunity for developing active ... -
HER2/neu-specific Breast Cancer Vaccine
Chen, Yuxiu (2013-01-18)Breast cancer is the most common cancer among women. Of all breast cancers cases, approximately 30 percent have amplification of the self-antigen HER2/neu. Later studies demonstrated that HER2/neu-specific antibody and T ... -
HIV-1 Glycoprotein 120-Specific Exosome-Targeted CD8+ T Cell Vaccine
Hebbandi Nanjundappa, Roopa (2012-02-10)Immunosuppression is a hallmark of human immunodeficiency virus-1 (HIV-1) infection. Upon binding to cluster of differentiation (CD) 4 receptor via trimeric glycoprotein (Gp) 120, HIV-1 enters and multiplies in CD4+ T ... -
IL-6-engineered DC stimulate efficient antitumor immunity via enhanced and prolonged T cell cytotoxicity and survival
Zhang, Bei (2009)Dendritic cells (DCs) modified by some immunomodulatory genes can stimulate a strong antitumor immunity and improve the treatment of tumor cells on the condition that the sources of tumor-associated antigens (TAAs) are ... -
The importance of the F4 receptor in post-weaned pigs In eliciting F4 specific immune responses in the intestine
Danabassis, Michael (2006-03-23)In this Master’s dissertation, various doses of solubulized crude F4 fimbrial protein in conjunction with the adjuvants CpG ODN and porcine â-defensin 1 (pBD-1) were used to enhance the F4-specific intestinal immune response ... -
Novel HIV-1 Gag-specific Exosome-targeted CD8+ T cell-Based Therapeutic Vaccine Capable of Converting CTL Exhaustion in Chronic Infection
Wang, Rong (2015-11-19)Human immunodeficiency virus type 1 (HIV-1) is the cause of acquired immune deficiency syndrome (AIDS). HIV-1 is a worldwide epidemic that currently affects over 35 million people worldwide, and continues to spread at an ... -
Release of Cardiac Biomarkers and Inflammatory Response during Cardiopulmonary Bypass: Comparison of Different Biocompatible Materials Used in Cardiopulmonary Bypass
Sohn, Namseok (2008)Coronary Artery Bypass Grafting (CABG) is an effective and invasive cardiac surgery to salvage blocked coronary artery. Cardiopulmonary bypass (CPB) is usually applied to support circulation during temporary cardiac arrest. ... -
Targeting Th (Th17 and Th2) suppressive and stimulatory effect on cytotoxic T cells
Ankathatti Munegowda, Manjunatha (2012-07-31)As the name indicates, T-helper cells are shown to help in primary and secondary cellular and humoral immune responses. They behave as conductors of immune responses. Conferring immunity to various kinds of antigens, the ... -
TRANSGENE IL-21-ENGINEERED ANTIGEN-SPECIFIC EXOSOME TARGETED T CELL-BASED VACCINE POTENTLY CONVERTS CTL EXHAUSTION IN CHRONIC INFECTION
Zhang, Xueying; 0000-0001-7764-6780 (2018-06-11)CD8+ cytotoxic T lymphocytes (CTLs), the potent effector T cells, capable of directly destroying virus-infected cells, correlate with acute viral control and long-term non-progression in virus-mediated infectious diseases, ...