The versatility of palladium systems: from palladacycles to cyclic peptides and beyond

Abstract

This work started with the aim to synthesize monomeric ring-opened analogues of the palladacycles [(iminoisoidoline)PdCl(PCy3)] incorporating iminoisoindoline and phosphine ligands, and evaluate their catalytic activities in C-C coupling reactions compared to their monomeric palladacyclic precursors. This project further evolved to investigate cyclic peptides derived from flaxseed oil as alternative ligands in palladium coordination chemistry for applications in C-C coupling reactions. During the course of our studies, we observed that cyclic peptides derived from flaxseed oil had a high affinity for first row transition metals.