Total Synthesis of vallartanone A
Date
2014-11-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
ORCID
Type
Thesis
Degree Level
Masters
Abstract
The research presented herein describes the first enantioselective total syntheses of vallartanone A and its (8R) epimer both starting with propanoic acid and isobutyraldehyde. The key steps involved a proline-catalyzed intermolecular aldol reaction and a second aldol reaction that proceeded with kinetic resolution. It is concluded that the absolute configuration of vallartanone A should be revised to (3S,4S,8S).
Description
Keywords
vallartanone, kinetic resolution, kinetic, resolution, aldol, total synthesis
Citation
Degree
Master of Science (M.Sc.)
Department
Chemistry
Program
Chemistry