Total Synthesis of vallartanone A
Lai, Leon Chun Kiu 1986-
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The research presented herein describes the first enantioselective total syntheses of vallartanone A and its (8R) epimer both starting with propanoic acid and isobutyraldehyde. The key steps involved a proline-catalyzed intermolecular aldol reaction and a second aldol reaction that proceeded with kinetic resolution. It is concluded that the absolute configuration of vallartanone A should be revised to (3S,4S,8S).
DegreeMaster of Science (M.Sc.)
CommitteeWard, Dale E; Dimmock, Jonathan R; Majewski, Marek
Copyright DateOctober 2014
vallartanone, kinetic resolution, kinetic, resolution, aldol, total synthesis