Total Synthesis of vallartanone A
Date
2014-11-12Author
Lai, Leon Chun Kiu 1986-
Type
ThesisDegree Level
MastersMetadata
Show full item recordAbstract
The research presented herein describes the first enantioselective total syntheses of vallartanone A and its (8R) epimer both starting with propanoic acid and isobutyraldehyde. The key steps involved a proline-catalyzed intermolecular aldol reaction and a second aldol reaction that proceeded with kinetic resolution. It is concluded that the absolute configuration of vallartanone A should be revised to (3S,4S,8S).
Degree
Master of Science (M.Sc.)Department
ChemistryProgram
ChemistryCommittee
Ward, Dale E; Dimmock, Jonathan R; Majewski, MarekCopyright Date
October 2014Subject
vallartanone, kinetic resolution, kinetic, resolution, aldol, total synthesis