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      • HARVEST
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      MECHANICAL METRICS OF THE PROXIMAL FEMUR ARE PRECISE AND ASSOCIATED WITH HIP MUSCLE PROPERTIES: A MAGNETIC RESONANCE BASED FINITE ELEMENT STUDY

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      MAJCHER-THESIS-2020.pdf (1.779Mb)
      Date
      2020-03-17
      Author
      Majcher, Kadin B 1994-
      ORCID
      0000-0001-8817-3261
      Type
      Thesis
      Degree Level
      Masters
      Metadata
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      Abstract
      Proximal femoral (hip) fractures are a life-threatening injury which affects 30,000 Canadians annually. Improved muscle and bone strength assessment methods may reduce fracture occurrence rates in the future. Magnetic resonance (MR) imaging has potential to assess proximal femoral bone strength in vivo through usage of finite element (FE) modeling. Though, to precisely assess bone strength, knowledge of a technique’s measurement error is needed. Hip muscle properties (e.g., lean muscle and fat area) are intrinsically linked to proximal femoral bone strength; however, it is unclear which muscles and properties are most closely associated with bone strength. This thesis is focused on MR-based FE modeling (MR-FE) of the proximal femur and surrounding muscle properties (e.g., hip abductor fat area, hip extensor muscle area). The specific objectives of this research were 1) to characterize the short-term in vivo measurement precision of MR-FE outcomes (e.g., failure load) of the proximal femur for configurations simulating fall and stance loading, and 2) explore associations between upper thigh muscle and fat properties (e.g., hip abductor fat area, knee extensor muscle area) with MR-FE failure loads of the proximal femur. In vivo precision errors (assessed via root mean square coefficient of variation, CV%RMS from repeated measures) of MR-FE outcomes ranged from 3.3-11.8% for stress and strain outcomes, and 6.0-9.5% for failure loads. Hip adductor muscle area and total muscle area correlated with failure load of the fracture-prone neck and intertrochanteric region under both fall and stance loading (correlation coefficients ranged from 0.416-0.671). This is the first study to report the in vivo short-term precision errors of MR-FE outcomes at the proximal femur. Also, this is the first study to relate upper-thigh muscle and fat properties with MR-FE derived failure loads. Results indicate that MR-FE outcomes have comparable precision to computed tomography (CT) based FE outcomes and are related to hip muscle area.
      Degree
      Master of Science (M.Sc.)
      Department
      Mechanical Engineering
      Program
      Mechanical Engineering
      Committee
      Dolovich, Allan; Leswick, David; Maw, Sean
      Copyright Date
      January 2020
      URI
      http://hdl.handle.net/10388/12698
      Subject
      Proximal Femur
      Finite Element
      MRI
      Bone strength
      Osteoporosis
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