Depression is a complex psychiatric disorder. It is recognized as a cyclical disease with multiple episode relapses. Many preclinical animal models have been utilized to study the behavioral and neurobiological characteristics ...

The experience of chronic stress plays an important role in the pathogenesis of major depressive disorder. Prolonged stress induces a state of chronically elevated glucocorticoid exposure in the brain, which is neurotoxic ...

Depression is a serious psychiatric disorder characterized by a range of debilitating symptoms. Long-term exposure to stress is a significant risk factor for the onset and maintenance of depression. Rats exposed to repeated ...

Stress is an important risk factor for the development of clinical depression, yet little is known about the neurobiological mechanisms by which stress might promote depressive symptomatology. The brain is particularly ...

Stress and depression are popular and powerful terms within the mental health field. Although the relation between the two terms has been discussed and investigated in lay and scientific discourse, less is known about how ...