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Antidepressant-Like Effects of Ketamine on Fear Conditioning and Extinction
The experience of chronic stress plays an important role in the pathogenesis of major depressive disorder. Prolonged stress induces a state of chronically elevated glucocorticoid exposure in the brain, which is neurotoxic ...
Fear Learning as a Component of a Depressive Phenotype in Rodents
Depression is a complex psychiatric illness that affects a large proportion of the population. Many researchers make use of preclinical animal models to study the behavioural and neurobiological characteristics of this ...
Antidepressant-like Effects of Peripheral Reelin Administration in a Preclinical Model of Depression
Depression is a serious psychiatric disorder characterized by a range of debilitating symptoms. Long-term exposure to stress is a significant risk factor for the onset and maintenance of depression. Rats exposed to repeated ...