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Creation, evaluation, and use of PSI, a program for identifying protein-phenotype relationships and comparing protein content in groups of organisms
(2009)
Recent advances in DNA sequencing technology have enabled entire genomes to be sequenced quickly and accurately, resulting in an exponential increase in the number of organisms whose genome sequences have been elucidated. ...
Scrambling analysis of ciliates
(2009-08)
Ciliates are a class of organisms which undergo a genetic process called gene descrambling after mating. In order to better understand the problem, a literature review of past works has been presented in this thesis. This ...
Methods for Transcriptome Assembly in the Allopolyploid Brassica napus
(2017-09-21)
Canada is the world’s largest producer of canola and the trend of production is ever increasing with an annual growth rate of 9.38% according to FAOSTAT. In 2017, canola acreage surpassed wheat in Saskatchewan, the highest ...
Microarray analysis using pattern discovery
(2004-11-05)
Analysis of gene expression microarray data has traditionally been conducted using hierarchical clustering. However, such analysis has many known disadvantages and pattern discovery (PD) has been proposed as an alternative ...
Techniques to Improve Deep Learning for Phenotype Prediction from Genotype Data
(2020-11-24)
We show that by representing Single Nucleotide Polymorphism (SNP) data to a neural network in a way that incorporates quality scores and avoids filtering out low quality SNPs we are able to increase the effectiveness of a ...
Enhancing Computational Methods for Strain Typing and Separating Strains of Mycoplasma bovis in Mixed Culture
(2020-12-02)
There are no programs that allow a user to isolate strain-specific sequences within a complex assembly
of mixed bacterial strains, unbiased by reference assembly. The tools that do exist each have a specialized
focus, such ...
The BioLighthouse: Reusable Software Design for Bioinformatics
(2020-10-29)
Advances in next-generation sequencing have accelerated the field of microbiology by making accessible a wealth of information about microbiomes. Unfortunately, microbiome experiments are among the least reproducible in ...