Now showing items 1-4 of 4
Examining an Animal Model of Depression with Recurrent Depression-like Episodes
Depression is a complex psychiatric disorder. It is recognized as a cyclical disease with multiple episode relapses. Many preclinical animal models have been utilized to study the behavioral and neurobiological characteristics ...
Antidepressant-Like Effects of Ketamine on Fear Conditioning and Extinction
The experience of chronic stress plays an important role in the pathogenesis of major depressive disorder. Prolonged stress induces a state of chronically elevated glucocorticoid exposure in the brain, which is neurotoxic ...
Antidepressant-like Effects of Peripheral Reelin Administration in a Preclinical Model of Depression
Depression is a serious psychiatric disorder characterized by a range of debilitating symptoms. Long-term exposure to stress is a significant risk factor for the onset and maintenance of depression. Rats exposed to repeated ...
Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
Stress is an important risk factor for the development of clinical depression, yet little is known about the neurobiological mechanisms by which stress might promote depressive symptomatology. The brain is particularly ...