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Antidepressant-Like Effects of Ketamine on Fear Conditioning and Extinction
The experience of chronic stress plays an important role in the pathogenesis of major depressive disorder. Prolonged stress induces a state of chronically elevated glucocorticoid exposure in the brain, which is neurotoxic ...
Fear Learning as a Component of a Depressive Phenotype in Rodents
Depression is a complex psychiatric illness that affects a large proportion of the population. Many researchers make use of preclinical animal models to study the behavioural and neurobiological characteristics of this ...
Self-discrepancies, depression proneness, and current mood state : a test of Higgins'and Ogilvie's theories
Higgins (1987) argued that perceived discrepancies between actual-self and ideal-self increase vulnerability to depression. Ogilvie (1987) argued that discrepancies between actual-self and undesired-self are more powerful ...
Patient and Physician Accounts of Antidepressant Requests in Primary Care
Depression is a nebulous term that is used in a variety of ways to account for a range of experiences usually characterized by low mood, lethargy, diminished pleasure from activities, among others. One prevalent way of ...
Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
Stress is an important risk factor for the development of clinical depression, yet little is known about the neurobiological mechanisms by which stress might promote depressive symptomatology. The brain is particularly ...