Browsing Graduate Theses and Dissertations by Subject "1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore"
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Cytotoxic thiol alkylators containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore
(2012-09-06)For the last several years curcumin has attracted considerable interest due to its ability to inhibit cancer cell proliferation in vitro and in vivo by targeting a number of different cell signaling and molecular mechanism ... -
Synthesis and bioactivities of novel N¹-acylhydrazides
(2018-09-25)Curcumin, a herbal polyphenol, has demonstrated anticancer activity in vitro as well as in vivo but have limited clinical benefits due to low oral bioavailability. Structural modification such as truncation of the β-diketone ...