University of SaskatchewanHARVEST
  • Login
  • Submit Your Work
  • About
    • About HARVEST
    • Guidelines
    • Browse
      • All of HARVEST
      • Communities & Collections
      • By Issue Date
      • Authors
      • Titles
      • Subjects
      • This Collection
      • By Issue Date
      • Authors
      • Titles
      • Subjects
    • My Account
      • Login
      JavaScript is disabled for your browser. Some features of this site may not work without it.
      View Item 
      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
      • View Item
      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
      • View Item

      MAGNETIC RESONANCE ELASTOGRAPHY FOR APPLICATIONS IN RADIATION THERAPY

      Thumbnail
      View/Open
      CUI-THESIS-2017.pdf (10.89Mb)
      Date
      2017-09-13
      Author
      Cui, Lumeng 1991-
      Type
      Thesis
      Degree Level
      Masters
      Metadata
      Show full item record
      Abstract
      Magnetic resonance elastography (MRE) is an imaging technique that combines mechanical waves and magnetic resonance imaging (MRI) to determine the elastic properties of tissue. Because MRE is non-invasive, there is great potential and interest for its use in the detection of cancer. The first part of this thesis concentrates on parameter optimization and imaging quality of an MRE system. To do this, we developed a customized quality assurance phantom, and a series of quality control tests to characterize the MRE system. Our results demonstrated that through optimizing scan parameters, such as frequency and amplitude, MRE could provide a good qualitative elastogram for targets with different elasticity values and dimensions. The second part investigated the feasibility of integrating MRE into radiation therapy (RT) workflow. With the aid of a tissue-equivalent prostate phantom (embedded with three dominant intraprostatic lesions (DILs)), an MRE-integrated RT framework was developed. This framework contains a comprehensive scan protocol including Computed Tomography (CT) scan, combined MRI/MRE scans and a Volumetric Modulated Arc Therapy (VMAT) technique for treatment delivery. The results showed that using the comprehensive information could boost the MRE defined DILs to 84 Gy while keeping the remainder of the prostate to 78 Gy. Using a VMAT based technique allowed us to achieve a highly conformal plan (conformity index for the prostate and combined DILs was 0.98 and 0.91). Based on our feasibility study, we concluded that MRE data can be used for targeted radiation dose escalation. In summary, this thesis demonstrates that MRE is feasible for applications in radiation oncology.
      Degree
      Master of Science (M.Sc.)
      Department
      Biomedical Engineering
      Program
      Biomedical Engineering
      Supervisor
      Venugopal, Niranjan; Babyn, Paul; Bui, Francis
      Committee
      McWalter, Emily; Alexander, Andrew; Eramian, Mark
      Copyright Date
      October 2017
      URI
      http://hdl.handle.net/10388/8085
      Subject
      MRE
      MRI
      Phantom
      QA
      Radiation Therapy
      Collections
      • Graduate Theses and Dissertations
      University of Saskatchewan

      University Library

      © University of Saskatchewan
      Contact Us | Disclaimer | Privacy