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      • HARVEST
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      ALDOL COUPLINGS OF CHIRAL FRAGMENTS WITH KINETIC RESOLUTION: SCOPE AND LIMITATIONS

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      KAZEMEINI-THESIS.pdf (1.022Mb)
      Date
      2013-02-25
      Author
      kazemeini, alieh
      Type
      Thesis
      Degree Level
      Masters
      Metadata
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      Abstract
      “The Thiopyran Route to Polypropionates” is a synthetic strategy that involves the stepwise aldol reactions of 6 and 7a to rapidly access stereochemically complex tetrapropionate 8 and hexapropionate synthons 72 or 73. Coupling racemic 7a with any of the four enantioenriched diastereomers 8 with kinetic resolution (KR) is possible with rational design of the reaction using the 'multiplicativity' rule. Thus, any of two of the eight possible aldol adducts, 72 or 73, are selectively available from the same reactants.
      Degree
      Master of Science (M.Sc.)
      Department
      Chemistry
      Program
      Chemistry
      Supervisor
      Ward, Dale
      Committee
      Majewski, Marek; Gravel, Michel; Attah-Poku, Samuel
      Copyright Date
      December 2011
      URI
      http://hdl.handle.net/10388/ETD-2011-12-244
      Subject
      Kinetic Resolution
      Collections
      • Graduate Theses and Dissertations
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