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dc.contributor.advisorHowland, John G.en_US
dc.creatorMacDougall, Matthewen_US
dc.date.accessioned2013-01-03T22:31:54Z
dc.date.available2013-01-03T22:31:54Z
dc.date.created2012-07en_US
dc.date.issued2012-09-11en_US
dc.date.submittedJuly 2012en_US
dc.identifier.urihttp://hdl.handle.net/10388/ETD-2012-07-535en_US
dc.description.abstractThe subiculum serves as the major output structure of the hippocampus; therefore, exploring synaptic plasticity within this region is of great importance for understanding the dynamics of hippocampal circuitry and hippocampal-cortical interactions. Exposure to acute stress dramatically alters synaptic plasticity within the hippocampal formation. Using in vivo electrophysiological recordings in urethane-anesthetized adult male Sprague-Dawley rats, we tested the effects of either acute restraint stress (30 min) or corticosterone (CORT) injections (3 mg/kg; s.c.) on short- and long-term forms of synaptic plasticity in the CA1-subiculum pathway. Paired-pulse facilitation and two forms of long-term plasticity (long-term potentiation and late-developing potentiation) were significantly reduced after exposure to acute stress but not acute CORT treatment. Measurements of plasma CORT confirmed statistically similar levels of circulating hormone in animals exposed to either acute stress or acute CORT treatment. The disruptive effects of acute stress on both short- and long-term form of synaptic plasticity are mediated by glucocorticoid receptor (GR) activation as these disruptions were blocked by pre-treatment with the selective GR antagonist RU38486 (10 mg/kg; s.c.). The present results highlight the susceptibility of subicular plasticity to acute stress and provide evidence that GR activation is a necessary but not a sufficient physiological parameter for mediating these alterations.en_US
dc.language.isoengen_US
dc.subjectPaired-pulse facilitation, Long-term potentiation, late-developing potentiation, Learning and Memory, Glucocorticoids, Hippocampusen_US
dc.titleAcute stress, but not corticosterone injections, disrupts both short- and long-term forms of synaptic plasticity in rat dorsal subiculum via glucocorticoid receptor activationen_US
thesis.degree.departmentPhysiologyen_US
thesis.degree.disciplinePhysiologyen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Science (M.Sc.)en_US
dc.type.materialtexten_US
dc.type.genreThesisen_US
dc.contributor.committeeMemberMulligan, Sean J.en_US
dc.contributor.committeeMemberFisher, Thomas E.en_US
dc.contributor.committeeMemberWest, Nigel H.en_US


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