University of SaskatchewanHARVEST
  • Login
  • Submit Your Work
  • About
    • About HARVEST
    • Guidelines
    • Browse
      • All of HARVEST
      • Communities & Collections
      • By Issue Date
      • Authors
      • Titles
      • Subjects
      • This Collection
      • By Issue Date
      • Authors
      • Titles
      • Subjects
    • My Account
      • Login
      JavaScript is disabled for your browser. Some features of this site may not work without it.
      View Item 
      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
      • View Item
      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
      • View Item

      Stiffness of the Proximal Tibial Bone in Normal and Osteoarthritic Conditions: A Parametric Finite Element Simulation Study

      Thumbnail
      View/Open
      Co-author permission of paper material reproduction.pdf (1.303Mb)
      SAGE_Dar2003.pdf (95.21Kb)
      Elsevier_Hayes1978.pdf (34.05Kb)
      Elsevier_Brown1984.pdf (34.02Kb)
      Elsevier_Bell2009.pdf (34.05Kb)
      AMINI-THESIS.pdf (2.399Mb)
      Date
      2013-04-16
      Author
      Amini, Morteza
      Type
      Thesis
      Degree Level
      Masters
      Metadata
      Show full item record
      Abstract
      Background: Osteoarthritis (OA) is a debilitating joint disease marked by cartilage and bone changes. Morphological and mechanical changes to bone, which are thought to increase overall bone stiffness, result in distorted joint mechanics and accelerated cartilage degeneration. Using a parametric finite element (FE) model of the proximal tibia, the primary objective of this study was to determine the relative and combined effects of OA-related osteophyte formation, and morphological and mechanical alterations to subchondral and epiphyseal bone on overall bone stiffness. The secondary objective was to assess how simulated bone changes affect load transmission in the OA joint. Methods: The overall geometry of the model was based on a segmented CT image of a cadaveric proximal tibia used to develop a 2D, symmetric, plane-strain, FE model. Simulated bone changes included osteophyte formation and varied thickness and stiffness (elastic modulus) in subchondral and epiphyseal bone layers. Normal and OA related values for these bone properties were based on the literature. “Effective Stiffness (K)” was defined as the overall stiffness of the proximal tibia, calculated using nodal displacement of the loaded area on the subchondral cortical bone surface and the load magnitude. Findings: Osteophyte formation and thickness or stiffness of the subchondral bone had little effect on overall bone stiffness. Epiphyseal bone stiffness had the most marked effect on overall bone stiffness. Load transmission did not differ between OA and normal bone. Interpretation: Results suggest that epiphyseal (trabecular) bone is a key site of interest in future analyses of OA and normal bone. Results also suggest that observed OA-related alterations in epiphyseal bone may result in OA bone being more flexible than normal bone.
      Degree
      Master of Science (M.Sc.)
      Department
      Mechanical Engineering
      Program
      Mechanical Engineering
      Supervisor
      Johnston, James D.; Szyszkowski, Walerian
      Committee
      Lanovaz, Joel L.; Szpunar, Jerzy A.
      Copyright Date
      January 2013
      URI
      http://hdl.handle.net/10388/ETD-2013-01-883
      Subject
      Stiffness, Osteoarthritis, Subchondral bone, Finite element analysis, Proximal tibia
      Collections
      • Graduate Theses and Dissertations
      University of Saskatchewan

      University Library

      © University of Saskatchewan
      Contact Us | Disclaimer | Privacy