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dc.contributor.advisorWang, Ruien_US
dc.creatorPeterson-Wakeman, Robert S.en_US
dc.date.accessioned2005-01-10T11:57:16Zen_US
dc.date.accessioned2013-01-04T04:23:41Z
dc.date.available2005-02-03T08:00:00Zen_US
dc.date.available2013-01-04T04:23:41Z
dc.date.created2004-12en_US
dc.date.issued2004-12-15en_US
dc.date.submittedDecember 2004en_US
dc.identifier.urihttp://hdl.handle.net/10388/etd-01102005-115716en_US
dc.description.abstractOur study investigated the potential for a combination of diabetes and nicotine treatment to affect blood pressure in the rat. We used streptozotocin injection and oral nicotine feeding as models of type-1 diabetes and smoking respectively. Blood pressure was assessed using the indirect tail-cuff technique. In an attempt to further characterize our experimental model, we also observed body weight, plasma glucose and the contractility of aortic segments in various treatment groups. Our data was expressed as mean ± SEM, and significance was regarded as P < 0.05. We found that a combination of streptozotocin and nicotine treatment resulted in a significant elevation of systolic blood pressure compared with either treatment alone, or control. Furthermore, assessment of aortic contractility showed alteration of reactivity to both phenylephrine and sodium nitroprusside as a result of the combination treatment. We also observed a trend for our combination treatment to exacerbate the elevation of plasma glucose level seen in streptozotocin induced diabetic rat models. This study serves as an experimental basis to underline the importance of cessation of tobacco use for individuals with diabetes mellitus.en_US
dc.language.isoen_USen_US
dc.subjectblood pressureen_US
dc.subjectcardiovascularen_US
dc.subjectdiabetesen_US
dc.subjectsmokingen_US
dc.subjectstreptozotocinen_US
dc.subjectnicotineen_US
dc.subjectraten_US
dc.subjectcombinationen_US
dc.titleEffects of nicotine and streptozotocin on the cardiovascular systemen_US
thesis.degree.departmentPhysiologyen_US
thesis.degree.disciplinePhysiologyen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Science (M.Sc.)en_US
dc.type.materialtexten_US
dc.type.genreThesisen_US
dc.contributor.committeeMemberWest, Nigelen_US
dc.contributor.committeeMemberTuchek, John M.en_US
dc.contributor.committeeMemberSulakhe, Prakashen_US
dc.contributor.committeeMemberPaterson, Phyllis G.en_US
dc.contributor.committeeMemberHemmings, Susanen_US


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