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      Study on dietary factors pertinent to the pathogenesis of heart failure in fast-growing commercial broilers

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      Date
      2008
      Author
      Nain, Sukhbir
      Type
      Thesis
      Degree Level
      Doctoral
      Metadata
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      Abstract
      A series of seven experiments were conducted to evaluate the risk of acute (sudden death syndrome; SDS) or chronic (congestive heart failure; CHF) heart failure associated with dietary over-supplementation of vitamin A, vitamin D3, vitamin E, vitamin C or cardiotoxic factors present in meat meal. The risk of heart failure associated with the above mentioned dietary factors was tested followed by gross, microscopic, ultrastructural and biochemical investigation for mechanisms associated with mentioned risk factors. Simultaneously, the molecular mechanisms underlying the deterioration of heart function in fast-growing commercial broilers were studied. Each compound was tested separately at a concentration higher than the recommended levels. The basic experimental unit comprised groups of 40 to 50 day old male broiler chickens at the start of experiment. Lowered thermal brooding temperature protocol, an approach resulting in clinical manifestation of heart failure in practically all broilers predisposed to heart disease, was used. Broilers fed the vitamin D3 enriched diet were 2.5 fold more likely to succumb to acute heart failure (p
      Degree
      Doctor of Philosophy (Ph.D.)
      Department
      Animal and Poultry Science
      Program
      Animal and Poultry Science
      Supervisor
      Laarveld, Bernard; Olkowski, Andrew A.
      Committee
      Drew, Murray D.; Classen, Henry L. (Hank); Cherian, Gita; Buchanan, Fiona C.; Alcorn, Jane; Wojnarowicz, Chris
      Copyright Date
      2008
      URI
      http://hdl.handle.net/10388/etd-02292008-195737
      Subject
      Heart Failure
      Meat Meal
      Broiler
      Vitamin
      Oxidative Stress
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      • Graduate Theses and Dissertations
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