Show simple item record

dc.contributor.advisorSingh, Jaswanten_US
dc.creatorMalhi, Pritpal Singhen_US
dc.date.accessioned2007-06-04T17:00:36Zen_US
dc.date.accessioned2013-01-04T04:34:42Z
dc.date.available2007-06-08T08:00:00Zen_US
dc.date.available2013-01-04T04:34:42Z
dc.date.created2007-06en_US
dc.date.issued2007-06-08en_US
dc.date.submittedJune 2007en_US
dc.identifier.urihttp://hdl.handle.net/10388/etd-06042007-170036en_US
dc.description.abstractDecline in fertility with age has been well documented in women. There are ethical limitations to use humans as a model for basic research, and there is a lack of well characterized animal model. The objective was to characterize and validate a bovine model for the study of age-associated subfertility. All experiments were conducted on the same group of 13-14 year old cows (n=10), and their 1-4 year old young daughters (n=10). Mother-daughter pairs were used to reduce genetic variations. Follicular wave pattern in a natural reproductive cycle was maintained in old cows similar to that in daughters. We hypothesized that aging in cattle is associated with elevated circulating concentrations of FSH, and reduced concentrations of steroid hormones. As stated, circulating FSH concentrations were higher (P=0.009) during follicular waves in old than young cows. The ovulatory follicle in 2-wave cycles was smaller in old cows (P=0.04), but plasma estradiol concentrations were higher (P=0.01). Luteal phase progesterone tended to be lower in old than young cows (P=0.1). The number of 4-5 mm follicles recruited into a follicular wave was lower (Pen_US
dc.language.isoen_USen_US
dc.subjectovaryen_US
dc.subjectreproductionen_US
dc.subjectagingen_US
dc.subjectbovine modelen_US
dc.subjectoocyteen_US
dc.titleA bovine model to study reproductive agingen_US
thesis.degree.departmentVeterinary Biomedical Sciencesen_US
thesis.degree.disciplineVeterinary Biomedical Sciencesen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophy (Ph.D.)en_US
dc.type.materialtexten_US
dc.type.genreThesisen_US
dc.contributor.committeeMemberSingh, Baljiten_US
dc.contributor.committeeMemberPierson, Roger A.en_US
dc.contributor.committeeMemberMapletoft, Reuben J.en_US
dc.contributor.committeeMemberBilodeau-Goeseels, Sylvieen_US
dc.contributor.committeeMemberAdams, Gregg P.en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record