The effect of water fluoridation on the bone mineral density of young women
Date
1996
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
ORCID
Type
Degree Level
Masters
Abstract
The effect of long term exposure to low level water fluoridation on
BMD (bone mineral density) was studied in a sample of female university
students (18 to 25 years). Subjects were 24 women from Regina,
Saskatchewan (natural level of fluoride in the drinking water is 0.1 mg./litre)
and 33 women from Saskatoon, Saskatchewan (supplementation of fluoride in
the drinking water is 1.0 mg./litre). These two cities are very similar in
population, climate and demographic data. The subjects had not moved
outside of their resident city for more than four years, had no bone affecting
medical disorders and were not using any bone affecting medications. All
subjects completed a lifestyle and dietary history evaluation and a food
frequency questionnaire. There were no differences between the two groups for
age, weight, height, bone mineral free lean mass, fat mass, estrogen status,
calcium and vitamin D intake, and past or present physical activity level.
Areal bone mineral density of the proximal femur, lumbar spine (AP
and lateral companion scan) and total body were measured using dual energy
x-ray absorptiometry (Hologic 2000, array mode). Volumetric BMD was also
determined for the lumbar spine from the AP and lateral companion spine
scans (VLS). The hypotheses predicted greater BMD in the fluoridated
community as compared to the non-fluoridated community, with the greatest
difference occuring at the axial skeleton. To determine an overall difference
in BMD between Regina and Saskatoon groups, MANCOVA was performed
with place of residence as the independent variable and AP Spine, Total Body
and Total Proximal Femur BMD as the dependent variables. Weight was used
as the covariate. There was a significant difference between Regina and
Saskatoon adjusted mean BMD (F (52,3) = 2.44, p < 0.05, one-tailed). Posthoc
univariate F-tests found the differences in BMD were due to differences at the AP Spine (Regina = 0.975 g/cm2
, Saskatoon = 1.039 g./cm2
, F (54, 1) =
7.33, p < 0.05, one-tailed), and Total Body (Regina= 1.044 g/cm2
, Saskatoon
= 1.073 g/cm2
, F (54,1) = 3.16, p < 0.05, one-tailed), but not at the proximal
femur. Based on the significant finding at the axial spine, ANCOVA was
performed for the lateral companion spine (L3) and VLS (L3). There was a
significant difference between the Regina and Saskatoon groups at VLS ((L3),
Regina= 0.216 g/cm3
, Saskatoon= 0.227 g/cm3
, F (53,1) = 4.37, p < 0.05,
one-tailed). This study supports that low level water fluoridation may have a
positive effect on the bone mineral density of young women, the greatest
effect occurring at the axial skeleton.
Description
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Citation
Degree
Master of Science (M.Sc.)
Department
College of Kinesiology
Program
College of Kinesiology