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      • HARVEST
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      The metabolism of vitamin K particularly vitamin K1

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      Taylor_Jack_Dean_1957_sec.pdf (9.706Mb)
      Date
      1957
      Author
      Taylor, Jack Dean
      Type
      Thesis
      Degree Level
      Doctoral
      Metadata
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      Abstract
      Our objectives were to study the distribution, transport, fate, and excretion of 2-methyl-C14-3-phytyl-1,4-naphthoquinone (referred to hereafter as vitamin K1-C14) in albino rats. Factors affecting the tissue distribution such as the route of administration, diet, pregnancy, age, and sex have been investigated. A comparison was made of the tissue deposition and excretion of C14 following the intravenous administration of 2-methyl-C14-1,4-naphthoquinone (referred to hereafter as vitamin K3- C14) and vitamin K1- C14 to rats. Isotope dilution tests were employed to ascertain the amount of vitamin K1- C14 that was present in the liver, skeletal muscle, spleen, bile, feces, and urine in unchanged form. Furthermore, attempts were made to isolate the metabolites of vitamin K1- C14 from urine and bile by ion exchange, column chromatography on Celite and alumina, and by paper chromatography.
      Degree
      Doctor of Philosophy (Ph.D.)
      Department
      Physiology and Pharmacology
      Program
      Physiology and Pharmacology
      Supervisor
      Lowethal, J.; Millar, G. J.
      Committee
      Pearce, J. W.; Jaques, L. B.; Spinks, J. W. T.
      Copyright Date
      1957
      URI
      http://hdl.handle.net/10388/etd-08092010-120854
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      • Graduate Theses and Dissertations
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