University of SaskatchewanHARVEST
  • Login
  • Submit Your Work
  • About
    • About HARVEST
    • Guidelines
    • Browse
      • All of HARVEST
      • Communities & Collections
      • By Issue Date
      • Authors
      • Titles
      • Subjects
      • This Collection
      • By Issue Date
      • Authors
      • Titles
      • Subjects
    • My Account
      • Login
      JavaScript is disabled for your browser. Some features of this site may not work without it.
      View Item 
      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
      • View Item
      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
      • View Item

      An investigation of intraperitoneal procaine penicillin G administration in lactating dairy cows

      Thumbnail
      View/Open
      chicoine.pdf (1.673Mb)
      Date
      2007-08-30
      Author
      Chicoine, Alan Leonard
      Type
      Thesis
      Degree Level
      Masters
      Metadata
      Show full item record
      Abstract
      This study describes the pharmacokinetic profile of procaine penicillin G after intraperitoneal (IP) administration in 8 lactating dairy cows. Procaine pencillin G (PPG, 21,000 IU/kg) was deposited into the abdominal cavity of each cow following an incision in the right paralumbar fossa. Blood and milk samples were taken over the following 10 days, at which point the cows were euthanized. Plasma, milk, muscle, liver, and kidney penicillin concentrations were determined by HPLC, with a limit of detection (LOD) of 5 ppb for plasma and milk samples. Noncompartmental methods were used to analyze plasma kinetics. The mean pharmacokinetic parameters ( } s.d.) were: Cmax, 5.5 } 2.6 ƒÊg/mL; Tmax, 0.75 } 0.27 h; AUC0- ‡, 10.8 } 4.9 ƒÊg*h/mL; MRT, 2.2 } 0.9 h. All milk from treated cows contained penicillin residues for a minimum of 3 milkings (31 h) and maximum of 5 milkings (52 h) after administration. Concentrations of penicillin G in all muscle, liver, and kidney samples taken 10 days post-administration were below the limit of detection. Necropsy examinations revealed foci of hemorrhage on the rumenal omentum of most cows but peritonitis was not observed. Systemic inflammation as determined by altered leukograms and fibrinogen was noted in one cow. The results of this study demonstrate that IP procaine penicillin G is absorbed and eliminated rapidly in lactating dairy cows.
      Degree
      Master of Science (M.Sc.)
      Department
      Veterinary Biomedical Sciences
      Program
      Veterinary Biomedical Sciences
      Supervisor
      Dowling, Patricia M.
      Committee
      Singh, Baljit; Boison, Joe O.
      Copyright Date
      August 2007
      URI
      http://hdl.handle.net/10388/etd-08282007-143429
      Subject
      drug residue
      penicillin
      pharmacokinetics
      antimicrobial
      milk residue
      Collections
      • Graduate Theses and Dissertations
      University of Saskatchewan

      University Library

      The University of Saskatchewan's main campus is situated on Treaty 6 Territory and the Homeland of the Métis.

      © University of Saskatchewan
      Contact Us | Disclaimer | Privacy