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      Dicoumarol studies with farm livestock

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      Linton_John_H_sec_1961.pdf (17.85Mb)
      Date
      1961
      Author
      Linton, John Herbert
      Type
      Thesis
      Degree Level
      Masters
      Metadata
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      Abstract
      The causal relationship between spoiled sweet clover and a hemor­rhagic condition in cattle was demonstrated by Schofield (31) in 1922. Since that time it has been found that the direct agent is dicoumarol, an anticoagulant causing hypoprothrombinemia and which is formed from coumarin during the spoilage process. All common varieties of sweet clover contain substantial amounts of coumarin, but recently a new coumarin variety "Cumino" has been developed in Canada. The low coumarin character, however, is deter­mined by a single recessive gene, consequently the variety may become rapidly contaminated because of cross-pollination with nearby stands or volunteer roadside sweet clover plants. Since contamination seems inevitable, the problem arises of establishing the relationship between the degree of contamination of low coumarin varieties and the potential risk involved in their use as feeds. Such information might be of value in establishing standards of varietal purity. The objectives of this study included comparisons of the responses by several classes of farm livestock to dicoumarol ingestion, attempts to deterrnine the levels of dicoumarol intake necessary to create blood coagulation disorders sufficient to endanger life of health, and the effects of vitamin K3 administered as a dietary supplement as a potential counteractant to dicoumarol.
      Degree
      Master of Science (M.Sc.)
      Department
      Animal Husbandry
      Program
      Animal Husbandry
      Supervisor
      Bell, John Milton
      Committee
      Williams, C. M.; Howell, William Edward
      Copyright Date
      1961
      URI
      http://hdl.handle.net/10388/etd-09022010-104812
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      • Graduate Theses and Dissertations
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