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dc.contributor.advisorKraatz, Heinz-Bernharden_US
dc.creatorKavianpour, Amir Houshangen_US
dc.date.accessioned2007-10-16T21:48:37Zen_US
dc.date.accessioned2013-01-04T05:01:19Z
dc.date.available2008-10-22T08:00:00Zen_US
dc.date.available2013-01-04T05:01:19Z
dc.date.created2007en_US
dc.date.issued2007en_US
dc.date.submitted2007en_US
dc.identifier.urihttp://hdl.handle.net/10388/etd-10162007-214837en_US
dc.description.abstractAlong with the rapid growth of the nanotechnology, nanoparticles (NPs) have found many applications in commercial products. However, there are only a few studies on the toxicity and the environmental effects of NPs in biological systems. In the study described in this thesis, I have used water-soluble Au NPs that were synthesized using the Brust method and then modified by small molecules. I explored the interactions of these modified Au NPs with self-assembled monolayer films on gold surfaces.Three types of self-assembled monolayer (SAM) modified gold surfaces were used in this study. The surfaces had SAMs that could be positively or negatively charged or carry no charge, or be able to engage in hydrogen bonding. Cyclic voltammetry (CV) was used to characterize SAMs of disulfide-glycine conjugate, disulfide-aspartic conjugate, and 11-mercaptoundecanoic acid (MUA) on gold surface electrodes. The possible interactions of Au NPs with the disulfide-aminoacid conjugates and alkanethiol modified surfaces were evaluated by cyclic voltammetry and by electrochemical impedance spectroscopy (EIS). An apparent decline in current density observed in CV along with an electron transfer resistance increase in EIS measurements upon exposure of the films to the MUA-modified anionic Au NPs clearly indicate interactions of the NPs with the films. Likewise, upon exposure of the films to cationic NPs, electron transfer resistance decreases dramatically in EIS experiments. In addition, the current increase in CV measurements provided further evidences for the interactions. The interactions between modified Au NPs and the SAMs were investigated in more detail by infrared spectroscopy and by employing quartz crystal microbalance. These studies clearly showed that upon exposure of these SAM films to the water-soluble Au NPs, significant changes occur. As would be expected for the adsorption of the Au NPs onto the SAMs, the weight of the film increased due to the addition of the NPs on the surface. Moreover, there are significant increases in the carbonyl stretching vibration at 1735 cm-1 along with the appearance of the amide hydrogen stretching band, between 3160-3380 cm-1, which indicate the adsorption of Gly-CSA modified Au NPs onto the MUA film.en_US
dc.language.isoen_USen_US
dc.subjectmonolayersen_US
dc.subjectimpedanceen_US
dc.subjectelectrochemistryen_US
dc.subjectinteractionsen_US
dc.subjectnanoparticlesen_US
dc.subjectbiomoleculesen_US
dc.titleA study on possible interactions between biomolecules and nanoparticlesen_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Science (M.Sc.)en_US
dc.type.materialtexten_US
dc.type.genreThesisen_US
dc.contributor.committeeMemberPan, Yuanmingen_US
dc.contributor.committeeMemberPaige, Matthew F.en_US
dc.contributor.committeeMemberGravel, Michelen_US


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