University of SaskatchewanHARVEST
  • Login
  • Submit Your Work
  • About
    • About HARVEST
    • Guidelines
    • Browse
      • All of HARVEST
      • Communities & Collections
      • By Issue Date
      • Authors
      • Titles
      • Subjects
      • This Collection
      • By Issue Date
      • Authors
      • Titles
      • Subjects
    • My Account
      • Login
      JavaScript is disabled for your browser. Some features of this site may not work without it.
      View Item 
      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
      • View Item
      • HARVEST
      • Electronic Theses and Dissertations
      • Graduate Theses and Dissertations
      • View Item

      Genetics of resistance to Trypanosoma congolense infection

      Thumbnail
      View/Open
      nq23918.pdf (7.072Mb)
      Date
      1993-01-01
      Author
      Ogunremi, Oladele Alabi
      Type
      Thesis
      Degree Level
      Doctoral
      Metadata
      Show full item record
      Abstract
      The principal goals of this investigation were (1) to study the inheritance of resistance to Trypanosoma congolense in mice, (2) to develop an assay for assessing the activity of the murine alternative pathway of complement based on its opsonizing activity, and (3) to determine if the opsonizing ability of the alternative pathway correlates with the genetic control of resistance to T. congolense in mice. To achieve these objectives, susceptible BALB/c and resistant C57BL/6 mice were crossed to produce reciprocal F1 and F2 generations. Ten-week old, female mice were infected with 103 T. congolense parasites. T. congolense became detectable in the blood of infected mice on day 4 in both susceptible and resistant mice and the growths of parasitaemia were similar for the next 24 hours. By day 6, BALB/c mice had higher parasitaemias than C57BL/6 mice (p $
      Degree
      Doctor of Philosophy (Ph.D.)
      Department
      Veterinary Microbiology
      Program
      Veterinary Microbiology
      Supervisor
      Tabel, Henry
      Copyright Date
      January 1993
      URI
      http://hdl.handle.net/10388/etd-10212004-000202
      Collections
      • Graduate Theses and Dissertations
      University of Saskatchewan

      University Library

      The University of Saskatchewan's main campus is situated on Treaty 6 Territory and the Homeland of the Métis.

      © University of Saskatchewan
      Contact Us | Disclaimer | Privacy