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dc.contributor.advisorCrossley, Margareten_US
dc.creatorMoorthy, Thamaraien_US
dc.date.accessioned2006-11-14T12:35:11Zen_US
dc.date.accessioned2013-01-04T05:08:21Z
dc.date.available2007-11-16T08:00:00Zen_US
dc.date.available2013-01-04T05:08:21Z
dc.date.created2006-11en_US
dc.date.issued2006-11-16en_US
dc.date.submittedNovember 2006en_US
dc.identifier.urihttp://hdl.handle.net/10388/etd-11142006-123511en_US
dc.description.abstractIndividuals with Alzheimer Disease (AD) exhibit deficits across multiple cognitive domains years before clinical diagnosis, when they are in the preclinical stages of the disease. Four studies were conducted to (a) examine the preclinical neuropsychological characteristics of English- and French-speaking Alzheimer Disease (AD) participants from the Canadian Study of Health and Aging (CSHA) and (b) determine the utility of select CSHA neuropsychological and demographic measures in predicting AD over a five-year period. Both English- and French-speaking AD participants demonstrated cognitive changes on episodic memory, verbal fluency, and speeded visuomotor processing tasks five years prior to diagnosis, however declines in performance between initial- and re-assessment were not uniform across these domains for either language group. Advanced age and declines in delayed episodic memory were the most significant indicators of progression to AD over a five-year period for both language groups. A validation study was conducted to investigate how well the predictors of AD prognosticate diagnostic outcome for an independent group of at-risk English-speaking participants. The best predictors of AD for the English-speaking group (age, episodic memory, and speeded visuomotor processing) accurately classified close to 70% of individuals from the at-risk sample. The present findings will contribute to diagnostic decisions regarding AD in older English- and French-speaking Canadian adults.en_US
dc.language.isoen_USen_US
dc.subjectAlzheimer Diseaseen_US
dc.subjectpredicting Alzheimer Diseaseen_US
dc.titlePredicting Alzheimer disease using premorbid neuropsychological performanceen_US
thesis.degree.departmentPsychologyen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophy (Ph.D.)en_US
dc.type.materialtexten_US
dc.type.genreThesisen_US
dc.contributor.committeeMemberHillis, Sarahen_US
dc.contributor.committeeMemberD'Arcy, Carlen_US
dc.contributor.committeeMemberMarche, Tammyen_US


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