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dc.contributor.advisorCorcoran, Michael E.en_US
dc.creatorWolfe, Kenneth Josephen_US
dc.date.accessioned2003-11-17T09:00:25Zen_US
dc.date.accessioned2013-01-04T05:08:31Z
dc.date.available2004-11-24T08:00:00Zen_US
dc.date.available2013-01-04T05:08:31Z
dc.date.created2003-10en_US
dc.date.issued2003-10-29en_US
dc.date.submittedOctober 2003en_US
dc.identifier.urihttp://hdl.handle.net/10388/etd-11172003-090025en_US
dc.description.abstractKindling involves the progressive development of epileptiform activity that culminates in generalized seizures in response to repeated electrical stimulation of the brain. Kindling induces widespread changes in synaptic sensitivity and neuronal reactivity. These neuroplastic changes are evident in altered memory and behavior. This research was designed to further our understanding of kindling-induced deficits in spatial cognition. Two questions were examined: 1)does entorhinal cortex kindling disrupt spatial cognition; and 2)can bilateral bifocal kindling, of two brain regions known to participate in spatial cognition, produce larger cognitive deficits than unifocal kindling? This research attempted to confirm the spatial cognitive effects produced by unifocal dorsal hippocampal (dHPC) kindling, as a positive control. In contrast, the spatial cognitive effects produce by unifocal entorhinal cortex (EC) and bifocal kindling (i.e., EC kindling with subsequent contralateral dHPC kindling) are unknown and were examined here. Rats were subjected to unifocal EC kindling, unifocal dHPC kindling, or bifocal kindling. Rats exhibited fully generalized seizures prior to Morris water maze training from days 2 to 31. Visible platform trials were used to examine escape motivation and gross motor coordination, and all groups performed adequately. Consistent with previous research, dHPC kindling disrupted performance during acquisition trials; however, EC and bifocal kindling failed to disrupt acquisition. During retention trials, the bifocal kindling group displayed a disruption in performance; however, dHPC and lateral EC kindling failed to affect retention. The bifocal kindled group failed to display larger deficits than the unifocal kindled groups. These data suggest that the number of kindling stimulations given to a particular site may play a critical role in site-dependent disruption of memory.en_US
dc.language.isoen_USen_US
dc.subjecthippocampusen_US
dc.subjectraten_US
dc.subjectspatial memoryen_US
dc.subjectkindlingen_US
dc.subjectbehavioren_US
dc.subjectentorhinal cortexen_US
dc.titleAn examination of Kindling's effect on spatial cognitionen_US
thesis.degree.departmentPsychiatryen_US
thesis.degree.disciplinePsychiatryen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Science (M.Sc.)en_US
dc.type.materialtexten_US
dc.type.genreThesisen_US
dc.contributor.committeeMemberTuchek, John M.en_US
dc.contributor.committeeMemberMousseau, Darrell D.en_US
dc.contributor.committeeMemberLi, Xin-Minen_US
dc.contributor.committeeMemberZhang, Xiaen_US


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