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dc.contributor.advisorSingh, Baljiten_US
dc.creatorJourneay, William Shaneen_US
dc.date.accessioned2007-12-04T20:19:21Zen_US
dc.date.accessioned2013-01-04T05:09:46Z
dc.date.available2008-12-06T08:00:00Zen_US
dc.date.available2013-01-04T05:09:46Z
dc.date.created2007en_US
dc.date.issued2007en_US
dc.date.submitted2007en_US
dc.identifier.urihttp://hdl.handle.net/10388/etd-12042007-201921en_US
dc.description.abstractA growing demand for information on the human health and environmental effects of materials produced using nanotechnology has led to a new area of investigation known as nanotoxicology. Research in this field has widespread implications in facilitating the medical applications of nanomaterials but also in addressing occupational and environmental toxicity concerns. Improving our understanding of these issues also has broad appeal in the stewardship of nanotechnology and its acceptance by the public. This work represents some of the early research in burgeoning field of nanotoxicology. Using a variety of in vivo and in vitro models, as well as cellular and molecular techniques I first studied a possible role for the novel cytokine endothelial monocyte activating polypeptide-II (EMAP-II) in acute lung inflammation in rats (Chapter 2). This work demonstrated a significant increase in total EMAP-II concentration in lipopolysaccharide inflamed lungs as early as 1h post-treatment (Pen_US
dc.language.isoen_USen_US
dc.subjectnanotoxicologyen_US
dc.subjectlung inflammationen_US
dc.subjectnanomedicineen_US
dc.subjectnanotechnologyen_US
dc.titleNanotoxicology : pulmonary toxicity studies on self-assembling rosette nanotubesen_US
thesis.degree.departmentToxicologyen_US
thesis.degree.disciplineToxicologyen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophy (Ph.D.)en_US
dc.type.materialtexten_US
dc.type.genreThesisen_US
dc.contributor.committeeMemberSharma, Rajendra K.en_US
dc.contributor.committeeMemberMisra, Vikramen_US
dc.contributor.committeeMemberKoehncke, Nielsen_US
dc.contributor.committeeMemberChan, Warrenen_US
dc.contributor.committeeMemberBlakley, Barry R.en_US


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