Effect of protein-energy malnutrition on nuclear factor kappa B activation following global ischemia
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Our laboratory previously found that protein-energy malnutrition (PEM) existing prior to brain ischemia impaired functional outcome measured in an open field test, and one-third of animals showed a marked increase in reactive gliosis. It was hypothesized that PEM worsened stroke outcome by increasing inflammation via increased activation of the transcription factor, nuclear factor kappa B (NFκB). Mongolian gerbils (11-12 wk old) were randomly assigned to a control diet (12.5% protein) or a protein-deficient diet (2%) for 28 days. The control group on average gained 4.9g and the PEM group lost 7.4g. PEM gerbils had significantly decreased food intake (P
DegreeMaster of Science (M.Sc.)
SupervisorPaterson, Phyllis G.
CommitteeNazarali, Adil J.; Bandy, Brian
Copyright DateDecember 2006
nuclear factor kappa B