The Total Synthesis of Depsilairdin

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Date
2009Author
Pardeshi, Sandip Govindsing
Type
ThesisDegree Level
DoctoralMetadata
Show full item recordAbstract
Dissertation describes of the first reported syntheses of the natural products lairdinol A and depsilairdin. The key steps in the synthesis of depsilairdin were N-terminal extension (C←N) of the protected proline fragment, hydrolysis of the tetrapeptide fragment with free secondary alcohol in the proline moiety and esterification of the HOBt ester of tetrapeptide fragment with the bromomagnesium alkoxide of lairdinol A.
Degree
Doctor of Philosophy (Ph.D.)Department
ChemistryProgram
ChemistrySupervisor
Ward, Dale ECommittee
Urquhart, Stephen; John, Balsevich; David, Palmer; Michel, GravelCopyright Date
2009Subject
blackleg disease
host-selective
phytotoxins
lairdinol A
depsilairdin