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Digital ulcers associated with scleroderma: a major unmet medical need

Date

2024-09

Authors

Naik, Angha
Stratton, Richard
Leask, Andrew

Journal Title

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Volume Title

Publisher

Wound Repair and Regeneration

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Article

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Abstract

Scleroderma or systemic sclerosis (SSc) associated digital ischemic complications, such as digital ulcers (SSc-DUs), appear relatively early during the disease course and are a major burden with substantial deterioration of quality of life. Expert rheumatologist and wound specialists have defined a DU; however, international application of the definition is still disorganized. Appearance of SSc-DUs is secondary to the onset of Raynaud’s phenomenon (RP) and as a consequence, recommended first-line of treatment mainly includes vasodilators; however, many DUs are refractory to this treatment. Despite important practical issues, such as a lack of well characterized SSc-wound healing animal model, significant efforts are needed to mechanistically understand the pathogenesis of SSc-DUs for developing clinically targetable disease modifying therapies.

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Keywords

chronic wound, connective tissue, rheumatology, scleroderma

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DOI

https://doi.org/10.1111/wrr.13224

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