ALDOL COUPLINGS OF CHIRAL FRAGMENTS WITH KINETIC RESOLUTION: SCOPE AND LIMITATIONS
Date
2013-02-25
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
ORCID
Type
Degree Level
Masters
Abstract
“The Thiopyran Route to Polypropionates” is a synthetic strategy that involves
the stepwise aldol reactions of 6 and 7a to rapidly access stereochemically complex
tetrapropionate 8 and hexapropionate synthons 72 or 73. Coupling racemic 7a with any
of the four enantioenriched diastereomers 8 with kinetic resolution (KR) is possible
with rational design of the reaction using the 'multiplicativity' rule. Thus, any of two of
the eight possible aldol adducts, 72 or 73, are selectively available from the same
reactants.
Description
Keywords
Kinetic Resolution
Citation
Degree
Master of Science (M.Sc.)
Department
Chemistry
Program
Chemistry