Bioinspired complex cellulose nanorod-architectures: A model for dual-responsive smart carriers
Date
2024-12-17
Authors
Heidari Nia, Marzieh
Garzia, Livia
Jawhar, Wajih
Wilson, Lee
van de Ven, Theo
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Elsevier
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Article
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Abstract
The synergy between nanomaterials as solid supports and supramolecular concepts has resulted in nanomaterials with hierarchical structure and enhanced functionality. Herein, we developed and investigated innovative supramolecular functionalities arising from the synergy between organic moieties and the preexisting nanoscale soft material backbones. Based on these complex molecular nano-architectures, a new nanorod carbohydrate polymer carrier was designed with bifunctional hairy nanocellulose (BHNC) to reveal dual-responsive advanced drug delivery (ADD). This carrier scavenges K+-ions within cancer cells, while simultaneously releasing doxorubicin, combining ion homeostasis disruption with targeted drug delivery. The BC ADD system resulted from cross-linking dibenzo-18-crown-6-ether (DB18C6) with BHNC particles. To enhance cellular internalization and facilitate tracking of uptake, the cellulose nanorod carrier was labeled with biotin and fluorescein isothiocyanate, referred to as BCFB. The BHNC serves as the backbone, while the immobilized DB18C6 moieties can capture doxorubicin via complex formation. The BCFB complex molecular nanorod carriers exhibit distinct ADD profiles with pH and K+-responsiveness. They were evaluated as biocompatible carriers for ADD in MDA-MB-231 breast cancer cells, including quantification of nanoparticle uptake and flow cytometry with KHOS cells. These cellulose-based carriers possess unique structure and properties with potential utility as phase transfer catalysts and as adsorbents for diverse waterborne contaminants.
Description
0144-8617/© 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by nc/4.0/).
Keywords
Bifunctional hairy nanocellulose, Crown ether, Supramolecular chemistry, Cellulose nanorod carriers, Bioimaging, Dual-responsive drug delivery systems
Citation
Marzieh Heidari Nia, Garzia, L., Wajih Jawhar, Wilson, L. D., & Theo. (2024). Bioinspired complex cellulose nanorod-architectures: A model for dual-responsive smart carriers. Carbohydrate Polymers, 352, 123162–123162. https://doi.org/10.1016/j.carbpol.2024.123162
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DOI
10.1016/j.carbpol.2024.123162