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DERIVATIVES OF 1-PHENYL-1-NONEN-3-ONE AS POTENTIAL BIOLOGICAL ALKYLATING AGENTS

Date

1973

Journal Title

Journal ISSN

Volume Title

Publisher

ORCID

Type

Degree Level

Doctoral

Abstract

The-preparation, spectroscopic properties and antineoplastic activities of a series of alkyl styryl ketones are presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating agents. The influence of aromatic substituents and the length of the alkyl side chain in relation to biological activity was undertaken. The olefinic bonds in the series of 1-(substituted phenyl)-1-nonen-3-ones had the E configuration. Infrared spectroscopy was useful for detecting mixtures of s-cis and s-trans rotational isomers.

Description

Keywords

alkylating agents, 1-PHENYL-1-NONEN-3-ONE

Citation

Degree

Doctor of Philosophy (Ph.D.)

Department

Pharmacy

Program

Advisor

Committee

Part Of

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DOI

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