The metabolism of vitamin K particularly vitamin K1
| dc.contributor.advisor | Lowethal, J. | en_US |
| dc.contributor.advisor | Millar, G. J. | en_US |
| dc.contributor.committeeMember | Pearce, J. W. | en_US |
| dc.contributor.committeeMember | Jaques, L. B. | en_US |
| dc.contributor.committeeMember | Spinks, J. W. T. | en_US |
| dc.creator | Taylor, Jack Dean | en_US |
| dc.date.accessioned | 2010-08-09T12:08:54Z | en_US |
| dc.date.accessioned | 2013-01-04T04:52:08Z | |
| dc.date.available | 2011-08-09T08:00:00Z | en_US |
| dc.date.available | 2013-01-04T04:52:08Z | |
| dc.date.created | 1957 | en_US |
| dc.date.issued | 1957 | en_US |
| dc.date.submitted | 1957 | en_US |
| dc.description.abstract | Our objectives were to study the distribution, transport, fate, and excretion of 2-methyl-C14-3-phytyl-1,4-naphthoquinone (referred to hereafter as vitamin K1-C14) in albino rats. Factors affecting the tissue distribution such as the route of administration, diet, pregnancy, age, and sex have been investigated. A comparison was made of the tissue deposition and excretion of C14 following the intravenous administration of 2-methyl-C14-1,4-naphthoquinone (referred to hereafter as vitamin K3- C14) and vitamin K1- C14 to rats. Isotope dilution tests were employed to ascertain the amount of vitamin K1- C14 that was present in the liver, skeletal muscle, spleen, bile, feces, and urine in unchanged form. Furthermore, attempts were made to isolate the metabolites of vitamin K1- C14 from urine and bile by ion exchange, column chromatography on Celite and alumina, and by paper chromatography. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10388/etd-08092010-120854 | en_US |
| dc.language.iso | en_US | en_US |
| dc.title | The metabolism of vitamin K particularly vitamin K1 | en_US |
| dc.type.genre | Thesis | en_US |
| dc.type.material | text | en_US |
| thesis.degree.department | Physiology and Pharmacology | en_US |
| thesis.degree.discipline | Physiology and Pharmacology | en_US |
| thesis.degree.grantor | University of Saskatchewan | en_US |
| thesis.degree.level | Doctoral | en_US |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) | en_US |