Repository logo
HARVEST
 

Studying bats using a One Health lens: bridging the gap between bat virology and disease ecology

Simple item page
dc.contributor.authorGonzalez, Victoria
dc.contributor.authorHurtado-Monzón, Arianna M.
dc.contributor.authorO'Krafka, Sabrina
dc.contributor.authorMühlberger, Elke
dc.contributor.authorLetko, Michael
dc.contributor.authorFrank, Hannah K.
dc.contributor.authorLaing, Eric D.
dc.contributor.authorPhelps, Kendra L.
dc.contributor.authorBecker, Daniel J.
dc.contributor.authorMunster, Vincent J.
dc.contributor.authorFalzarano, Darryl
dc.contributor.authorSchountz, Tony
dc.contributor.authorSeifert, Stephanie N.
dc.contributor.authorBanerjee, Arinjay
dc.date.accessioned2025-05-08T23:54:48Z
dc.date.available2025-05-08T23:54:48Z
dc.date.issued2024-12
dc.description.abstractAccumulating data suggest that some bat species host emerging viruses that are highly pathogenic in humans and agricultural animals. Laboratory-based studies have highlighted important adaptations in bat immune systems that allow them to better tolerate viral infections compared to humans. Simultaneously, ecological studies have discovered critical extrinsic factors, such as nutritional stress, that correlate with virus shedding in wild-caught bats. Despite some progress in independently understanding the role of bats as reservoirs of emerging viruses, there remains a significant gap in the molecular understanding of factors that drive virus spillover from bats. Driven by a collective goal of bridging the gap between the fields of bat virology, immunology, and disease ecology, we hosted a satellite symposium at the 2024 American Society for Virology meeting. Bringing together virologists, immunologists, and disease ecologists, we discussed the intrinsic and extrinsic factors such as virus receptor engagement, adaptive immunity, and virus ecology that influence spillover from bat hosts. This article summarizes the topics discussed during the symposium and emphasizes the need for interdisciplinary collaborations and resource sharing.
dc.description.sponsorshipV.G. is supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) scholarship. E.M. is supported by the European Health and Digital Executive Agency grant 101095712, OneBAT, and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIAID/NIH; R21AI137793 and R21AI169646). M.L. is supported by NIAID/NIH (R21AI169527 and R01AI179720). D.J.B. was supported by the National Institute of General Medical Sciences of the National Institutes of Health (P20GM134973), a Ralph E. Powe Junior Faculty Enhancement Award from Oak Ridge Associated Universities, and the Research Corporation for Science Advancement (RCSA). This work was conducted as part of Subaward No. 29018, part of a United States Department of Agriculture Non-312 Assistance Cooperative Agreement with RCSA Federal Award No. 58–3022-0-005. Support was also provided by the Vice President for Research and Partnerships of the University of Oklahoma and the Data Institute for Societal Challenges. Research within A.B.’s lab is supported by an NSERC Discovery Grant (RGPIN-2022–03010), Canadian Institutes of Health Research (CIHR)-Institute for Infection and Immunity Early Career Research grant (PTT-192089), CIHR-Pandemic Preparedness and Health Emergencies Early Career Investigator grant (PEE-183995), and CIHR-Institute for Infection and Immunity, Project grant (PJT-195787). VIDO receives operational funding from the Government of Saskatchewan through Innovation Saskatchewan and the Ministry of Agriculture and from the Canada Foundation for Innovation through the Major Science Initiatives Fund. V.J.M is supported by the Division of Intramural research of the National Institute of Allergy and Infectious Diseases. E.D.L is an employee of the US Government, and this work was prepared as part of their official duties. The content of the information does not necessarily reflect the position or the policy of the Uniformed Services University, US Department of Defense, the Department of the Navy, or the US Government, and no official endorsement should be inferred. K.L.P. was sponsored by the Department of Defense, Defense Threat Reduction Agency (HDTRA11710064). T.S. was supported by the NIAID (R01AI140442, R24AI165424 and R01AI134768), and the National Science Foundation (NSF; 2033260). H.K.F. was supported by NSF (DEB 1404521, IOS 2032157), NIH (5 R21 AI169548), a Life Sciences Research Foundation Fellowship, and the Open Philanthropy Project. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. S.N.S was partly supported by the NIH Centre for Research in Emerging Infectious Diseases-East and Central Africa (CREID-ECA; U01AI151799). D.J.B, H.K.F., and S.N.S were also supported by the NSF (BII 2213854); the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Science Foundation or the Verena Institute.
dc.description.versionPeer Reviewed
dc.identifier.citationGonzalez, V., Hurtado-Monzón, A. M., O’Krafka, S., Mühlberger, E., Letko, M., Frank, H. K., Laing, E. D., Phelps, K. L., Becker, D. J., Munster, V. J., Falzarano, D., Schountz, T., Seifert, S. N., Banerjee, A., & Mukhopadhyay, S. (2024). Studying bats using a One Health lens: bridging the gap between bat virology and disease ecology. Journal of Virology, 98(12), e0145324-. Gonzalez, V., Hurtado-Monzón, A. M., O’Krafka, S., Mühlberger, E., Letko, M., Frank, H. K., Laing, E. D., Phelps, K. L., Becker, D. J., Munster, V. J., Falzarano, D., Schountz, T., Seifert, S. N., Banerjee, A., & Mukhopadhyay, S. (2024). Studying bats using a One Health lens: bridging the gap between bat virology and disease ecology. Journal of Virology, 98(12), e0145324-. https://doi.org/10.1128/jvi.01453-24
dc.identifier.doihttps://doi.org/10.1128/jvi.01453-24
dc.identifier.urihttps://hdl.handle.net/10388/16921
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rightsAttribution 2.5 Canadaen
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/ca/
dc.subjectbats
dc.subjectvirology
dc.subjectdisease ecology
dc.subjectimmunity
dc.subjectASV 2024
dc.subjectsatellite symposium
dc.titleStudying bats using a One Health lens: bridging the gap between bat virology and disease ecology
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gonzalez_etal_Studying_Bats_One_Health.pdf
Size:
922.82 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.36 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

VIDO-InterVac
One Health