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Using synchrotron imaging techniques to solve problems in neurosurgery

dc.contributor.advisorJuurlink, BHJen_US
dc.contributor.advisorChapman, Deanen_US
dc.contributor.committeeMemberNichol, Hen_US
dc.contributor.committeeMemberFourney, Den_US
dc.contributor.committeeMemberMayer, Men_US
dc.contributor.committeeMemberPaterson, Pen_US
dc.contributor.committeeMemberWest, Men_US
dc.creatorKelly, Michaelen_US
dc.date.accessioned2010-12-01T23:28:20Zen_US
dc.date.accessioned2013-01-04T05:09:41Z
dc.date.available2011-12-08T08:00:00Zen_US
dc.date.available2013-01-04T05:09:41Z
dc.date.created2010-02en_US
dc.date.issued2010-02en_US
dc.date.submittedFebruary 2010en_US
dc.description.abstractObjective: The purpose of the research presented in this thesis is to explore new biomedical applications of synchrotron imaging in the field of neurosurgery. Methods: Four different studies were performed, all using advanced biomedical synchrotron imaging techniques. In the first two experiments, diffraction enhanced imaging (DEI) and analyzer based imaging (ABI) were utilized to study the anatomy of the rat spine and a novel rat model of spinal fusion. In a third experiment, K-edge digital subtraction angiography (KEDSA) was used to study the cerebral vasculature in a rabbit model. In a fourth experiment, rapid scanning X-ray fluorescence spectroscopy (RS-XRF) was used to study stem cell migration in a rat stroke model. Results: DEI had superior visualization of ligamentous and boney anatomy in a rat model. Analyzer based imaging was able to visualize physiologic amounts of bone graft material and progressive incorporation into the spine. Intravenous KEDSA showed excellent visualization of the cerebral vasculature in a rabbit model. Finally, RS-XRF was used to track iron labeled stem cells implanted in a rat stroke model. The technique was able to visualize the iron that represented the stem cell migration. This was correlated with histology and magnetic resonance imaging information. Conclusions: 1) Diffraction enhanced imaging has excellent contrast for the study of boney and ligamentous anatomy. 2) Analyzer based imaging is an excellent tool to study animal models of boney fusion. 3) Intravenous KEDSA is able to clearly visualize the arterial vasculature in a rabbit model. 4) RS-XRF can be used to study the migration patterns of implanted iron labeled stem cells.en_US
dc.identifier.urihttp://hdl.handle.net/10388/etd-12012010-232820en_US
dc.language.isoen_USen_US
dc.subjectSynchrotronen_US
dc.subjectneurosurgery imagingen_US
dc.titleUsing synchrotron imaging techniques to solve problems in neurosurgeryen_US
dc.type.genreThesisen_US
dc.type.materialtexten_US
thesis.degree.departmentAnatomy and Cell Biologyen_US
thesis.degree.disciplineAnatomy and Cell Biologyen_US
thesis.degree.grantorUniversity of Saskatchewanen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophy (Ph.D.)en_US

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