The Total Synthesis of Depsilairdin
Date
2009
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
ORCID
Type
Degree Level
Doctoral
Abstract
Dissertation describes of the first reported syntheses of the natural products lairdinol A and depsilairdin. The key steps in the synthesis of depsilairdin were N-terminal extension (C←N) of the protected proline fragment, hydrolysis of the tetrapeptide fragment with free secondary alcohol in the proline moiety and esterification of the HOBt ester of tetrapeptide fragment with the bromomagnesium alkoxide of lairdinol A.
Description
Keywords
blackleg disease, host-selective, phytotoxins, lairdinol A, depsilairdin
Citation
Degree
Doctor of Philosophy (Ph.D.)
Department
Chemistry
Program
Chemistry