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The Total Synthesis of Depsilairdin

Date

2009

Journal Title

Journal ISSN

Volume Title

Publisher

ORCID

Type

Degree Level

Doctoral

Abstract

Dissertation describes of the first reported syntheses of the natural products lairdinol A and depsilairdin. The key steps in the synthesis of depsilairdin were N-terminal extension (C←N) of the protected proline fragment, hydrolysis of the tetrapeptide fragment with free secondary alcohol in the proline moiety and esterification of the HOBt ester of tetrapeptide fragment with the bromomagnesium alkoxide of lairdinol A.

Description

Keywords

blackleg disease, host-selective, phytotoxins, lairdinol A, depsilairdin

Citation

Degree

Doctor of Philosophy (Ph.D.)

Department

Chemistry

Program

Chemistry

Part Of

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DOI

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