REDUCTIVE CYCLIZATIONS BY MEANS OF SODIUM BOROHYDRIDE AND PALLADIUM-CHARCOAL
Date
1968-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
ORCID
Type
Degree Level
Masters
Abstract
In the course of his investigations into the syntheses of hydroxamic acids Coutts became involved in a study of the reducing properties of sodium borohydride in the presence of palladium-charcoal. The purpose of this thesis is to determine whether it is possible to extend
this study to the preparation of novel heterocyclic N-hydroxy compounds.
The emphasis of Coutts' studies to date has been on the preparation of cyclic hydroxamic acids, compounds which have aroused interest only in recent years. In 1943, White (1) discovered that the filtrate from cultures of certain strains of Aspergillus flavus possessed antibacterial activity against various gram negative and gram positive bacteria. Further investigation (2) attributed this action to a metabolite, aspergillic acid (I), which was isolated from the filtrate.
Description
Keywords
novel heterocyclic N-hydroxy compounds
Citation
Degree
Master of Science (M.Sc.)
Department
Pharmacy