PRODRUGS AND DERIVATIVES OF ALPHA, BETA-UNSATURATED KETONES DESIGNED AS ANTICANCER AGENTS
| dc.creator | Patil, Shirish A. | |
| dc.date.accessioned | 2023-11-17T19:29:43Z | |
| dc.date.available | 2023-11-17T19:29:43Z | |
| dc.date.issued | 1986 | |
| dc.date.submitted | 1986 | en_US |
| dc.description.abstract | In the chemotherapy of cancer, a number of different classes of drugs are used. Of these, alkylating agents constitute about 30% and while a few of the less common cancers can be effectively treated by chemotherapy or adjuvant therapy, the drugs are marked by lack of specificity and high toxicity. Moreover, the vast majority of cancers cannot be treated satisfactorily by any therapy at all. Therefore, there is a need for better and more selective anticancer drugs. The present project may be considered to consist of the following two areas. I) Design, synthesis and antineoplastic evaluation) of novel candidate antineoplastics of the type- a) Mannich bases and related compounds. b)0G,13-Unsaturated ketones and their derivatives. II) Physicochemical, stability and in vitro studies of selected compounds. The compounds were designed as alkylating agents so that they would alkylate important biomacromolecules in the rapidly proliferating cancer cells. They were, therefore, either strong alkylators per se or were designed to generate such a species in vivo. | en_US |
| dc.identifier.uri | https://hdl.handle.net/10388/15269 | |
| dc.title | PRODRUGS AND DERIVATIVES OF ALPHA, BETA-UNSATURATED KETONES DESIGNED AS ANTICANCER AGENTS | en_US |
| dc.type.genre | Thesis | en_US |
| thesis.degree.department | Pharmacy | en_US |
| thesis.degree.grantor | University of Saskatchewan | en_US |
| thesis.degree.level | Doctoral | en_US |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) | en_US |