Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks
Date
2020-11
Authors
Berkenbrock, José Alvim
Grecco-Machado, Rafaela
Achenbach, Sven
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The Royal Society Publishing
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Article
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Abstract
Extensive testing of populations against COVID-19 has been suggested as a game-changer quest to control the spread of this contagious disease and to avoid further disruption in our social, healthcare and economical systems. Nonetheless, testing millions of people for a new virus brings about quite a few challenges. The development of effective tests for the new coronavirus has become a worldwide task that relies on recent discoveries and lessons learned from past outbreaks. In this work, we review the most recent publications on microfluidics devices for the detection of viruses. The topics of discussion include different detection approaches, methods of signalling and fabrication techniques. Besides the miniaturization of traditional benchtop detection assays, approaches such as electrochemical analyses, field-effect transistors and resistive pulse sensors are considered. For emergency fabrication of quick test kits, the local capabilities must be evaluated, and the joint work of universities, industries, and governments seems to be an unequivocal necessity.
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Keywords
COVID-19, SARS-CoV-2, microfluidicdevices, microfabrication, nanofabrication, viruses
Citation
Berkenbrock José Alvim, Grecco-Machado Rafaela and Achenbach Sven 2020Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaksProc. R. Soc. A.47620200398 http://doi.org/10.1098/rspa.2020.0398
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DOI
https://doi.org/10.1098/rspa.2020.0398