THE EFFECTS OF DIETARY GUAR GUM AND CELLULOSE IN THE DIABETIC RAT
| dc.contributor.advisor | Olson, J. P. | |
| dc.contributor.committeeMember | Bell | |
| dc.creator | Rose, Heather E. | |
| dc.date.accessioned | 2023-12-21T21:55:48Z | |
| dc.date.available | 2023-12-21T21:55:48Z | |
| dc.date.issued | 1980-08 | |
| dc.date.submitted | August 1980 | |
| dc.description.abstract | The metabolic effects of two dietary fibers, guar gum and cellulose, were investigated in insulin-treated, alloxan-diabetic rats. The diabetic rats fed a basal purified diet diluted with various levels of guar gum tended to have lower serum glucose concentrations (P>0.05) than the rats fed the basal diet diluted with the same levels of cellulose. An equivalent state of diabetic control (as evidenced by the similar serum cholesterol and triglyceride concentrations, the liver enzyme activities and the growth rates of the diabetic and the nondiabetic rats) was attained in all dietary treatments. However, the exogenous insulin requirements of the diabetic rats fed the guar gum diets were lower (P40.01) than the requirements of the rats fed the cellulose diets. The difference remained-significant (P40.05) after adjustment of the insulin requirements with body weights. Serum lipid levels were similar in both the diabetic and nondiabetic rats. A positive correlation was found between the serum glucose levels and the:5-hour fasted serum trigly-ceride concentrations (r2=0.05). - No linear relationship was found between the serum glucose and the serum cholesterol levels (r2=0.002). The growth of the rats decreased as the level of fiber dilution of the diet increased; the reduction in growth was greater in the rats fed the guar, as compared to the cellulose diets (1, 0.01). Although the dry matter digestibilities of the guar diets were higher than the cellulose diets, the adjustment of the weight gains of the rats with the energy consumed resulted in no differences remaining between treat-ments- The smaller feed intakes, and hence weight gains, of the rats fed the guar as compared to the cellulose diets, were concluded to be due to the different physical properties of the two fibers. The satiety of the rats fed the guar diluted diets may have been increased by the greater viscosity of the digesta, or, alternatively, gastrointestinal discomfort may have been caused by the distension of the gut. In conclusion, guar gum, but not cellulose, was effect-ive in reducing the serum glucose levels and the exogenous insulin requirements of the alloxan diabetic rat. The difference in action of the two fibers could not, be accounted for by differences in the feed intake patterns, the hepatic enzyme activities, the gastrointestinal transit times or the dry matter digestibilities of the diets. | |
| dc.identifier.uri | https://hdl.handle.net/10388/15386 | |
| dc.subject | dietary fibers | |
| dc.title | THE EFFECTS OF DIETARY GUAR GUM AND CELLULOSE IN THE DIABETIC RAT | |
| dc.type.genre | Thesis | |
| thesis.degree.department | Home Economics | |
| thesis.degree.grantor | University of Saskatchewan | en_US |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.Sc.) |