THE CIRCADIAN RHYTHM OF SERUM INORGANIC SULFATE LEVELS AND ACETAMINOPHEN CHRONOPHARMACOKINETICS
| dc.creator | Hoffman, Donald Adam | |
| dc.date.accessioned | 2023-12-21T21:24:28Z | |
| dc.date.available | 2023-12-21T21:24:28Z | |
| dc.date.issued | 1989 | |
| dc.date.submitted | 1989 | |
| dc.description.abstract | Conjugation with inorganic sulfate is an important route of metabolism for many xenobiotics and endogenous compounds. The inorganic sulfate concentration in blood is one of several factors that might limit the rate of substrate sulfation in vivo. Factors affecting the physiological availability and disposition of inorganic sulfate therefore may be important in sulfoconjugation processes. This study confirmed a small but consistent circadian variation of serum inorganic sulfate levels in healthy men. Acetaminophen, a common analgesic/antipyretic, can cause a gradual depletion of inorganic sulfate in the body when administered in a variety of doses by different routes. The administration of acetaminophen in subchronic doses decreased the but did not abolish the circadian clearance of inorganic sulfate at serum inorganic sulfate levels rhythm. Decreased renal depressed serum sulfate levels (during acetaminophen administration) is consistent with conservation of inorganic sulfate by increased tubular reabsorption. No significant chronopharmacokinetic changes in the sulfation of acetaminophen at steady state between the AM and PM administration periods were noted. | |
| dc.identifier.uri | https://hdl.handle.net/10388/15383 | |
| dc.title | THE CIRCADIAN RHYTHM OF SERUM INORGANIC SULFATE LEVELS AND ACETAMINOPHEN CHRONOPHARMACOKINETICS | |
| dc.type.genre | Thesis | |
| thesis.degree.department | Pharmacy | |
| thesis.degree.grantor | University of Saskatchewan | en_US |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.Sc.) |