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A CHEMICAL INVESTIGATION OF THE GENUS MENTZELIA

Date

1972

Journal Title

Journal ISSN

Volume Title

Publisher

ORCID

Type

Degree Level

Doctoral

Abstract

A chemical examination of Mentzelia decapetala is described. Paper chromatographic techniques allowed the detection of glucose, fructose, sucrose, and several gluc-osidic principles in crude plant extracts. A new chromat-ographic method for the specific detection of iridoid gluc-osides in plant extracts was developed and is outlined. This procedure allowed the detection of at least three iri-doid glucosides in extracts of M. decapetala. The first of these iridoid glucosides was isolated by chromatographic procedures and was characterized by instrumental analysis of the parent glucoside and its prepared derivatives. This compound, mentzeloside (CIV), was also isolated from Mentzelia laevicaulie. The structure of a second iridoid, decaloside (CV) was assigned by instrumental analysis and by analogy with mentzeloside. The derivation of the gross structures and absolute stereo-chemistries of these compounds is described in detail in this presentation. A flavonol glycoside, shown to be rutin (XCVI) was also isolated from M. decapetala. Pharmacological testing results for mentzeloside and its aglycone, mentzelol (CVII) are reported.

Description

Keywords

Mentzelia decapetala, iridoid glucosides

Citation

Degree

Doctor of Philosophy (Ph.D.)

Department

Pharmacy

Program

Advisor

Committee

Part Of

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DOI

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