A CHEMICAL INVESTIGATION OF THE GENUS MENTZELIA
Date
1972
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
ORCID
Type
Degree Level
Doctoral
Abstract
A chemical examination of Mentzelia decapetala is described. Paper chromatographic techniques allowed the detection of glucose, fructose, sucrose, and several gluc-osidic principles in crude plant extracts. A new chromat-ographic method for the specific detection of iridoid gluc-osides in plant extracts was developed and is outlined. This procedure allowed the detection of at least three iri-doid glucosides in extracts of M. decapetala.
The first of these iridoid glucosides was isolated by chromatographic procedures and was characterized by instrumental analysis of the parent glucoside and its prepared derivatives. This compound, mentzeloside (CIV), was also isolated from Mentzelia laevicaulie. The structure
of a second iridoid, decaloside (CV) was assigned by instrumental analysis and by analogy with mentzeloside. The derivation of the gross structures and absolute stereo-chemistries of these compounds is described in detail in this presentation.
A flavonol glycoside, shown to be rutin (XCVI) was also isolated from M. decapetala.
Pharmacological testing results for mentzeloside and its aglycone, mentzelol (CVII) are reported.
Description
Keywords
Mentzelia decapetala, iridoid glucosides
Citation
Degree
Doctor of Philosophy (Ph.D.)
Department
Pharmacy