Effect of adding potassium bicarbonate or sodium bicarbonate on high protein induced hypercalciuria
| dc.contributor.advisor | Whiting, Susan | |
| dc.creator | Green, Timothy John | |
| dc.creator.orcid | 0000-0002-0667-4300 | |
| dc.date.accessioned | 2022-12-13T19:05:42Z | |
| dc.date.available | 2022-12-13T19:05:42Z | |
| dc.date.issued | 1993-08 | |
| dc.date.submitted | August 1993 | en_US |
| dc.description.abstract | Alkaline potassium salts such as potassium bicarbonate and potassium citrate have been reported to reduce urinary calcium excretion when administered to subjects consuming moderate protein diets. Sodium bicarbonate administration has been reported to reduce the hypercalciuria induced by a high protein diet. Studies of subjects consuming a moderate protein diet, however, have failed to show a hypocalciuric effect of sodium bicarbonate. Due to the contradictory findings of the effects of sodium bicarbonate on urinary calcium excretion, one of the objectives of the present study was to clarify the effect of sodium bicarbonate on high protein- induced hypercalciuria. The second objective was to establish the effect of potassium bicarbonate on high protein induced hypercalciuria. The study was divided into five experimental weeks for a total length of 33 days. Eight healthy males were fed a moderate protein (MP) diet and, randomly, each of the following supplements for four day periods: 60 g protein (HP), 60 g protein + 90 mmol sodium bicarbonate (HP+Na), and 60 g protein + 90 mmol potassium bicarbonate (HP+K). Diets were similar in energy, calcium, and phosphorus. Subjects provided a 24-hour urine sample on Day 3 and Day 4 and a fasting urine and blood sample on Day 5 of each experimental week. As expected, both Day 3 and Day 4 urinary calcium excretion were significantly increased during the HP treatment relative to the MP treatment, by 58% and 40% respectively. On Day 3, adding sodium bicarbonate to the HP treatment reduced urinary calcium excretion by 25%. This hypocalciuric effect of sodium bicarbonate disappeared on Day 4. With the addition of potassium bicarbonate, both Day 3 and Day 4 urinary calcium excretion was reduced relative to the HP treatment by 39% and 47% respectively. The addition of potassium bicarbonate reduced urinary calcium excretion to the level of the MP treatment. On both Day 3 and Day 4, net acid excretion (NAE) was significantly higher during the HP treatment relative to the MP treatment. The addition of bicarbonate as either potassium bicarbonate or sodium bicarbonate resulted in significantly reduced NAE, to levels below those of either the HP and MP treatments. Day 4 urinary phosphate excretion was reduced during the HP+K treatment relative to the other three treatments. There were no significant changes in the levels of serum calcitriol or in the urinary excretion of hydroxypyridinium compounds. This experiment suggests that sodium bicarbonate does not have a sustained effect on high protein induced hypercalciuria. A study of longer duration may be necessary, however, to fully clarify the action of sodium bicarbonate. In addition, this experiment demonstrated that potassium bicarbonate reduces high protein induced hypercalciuria to levels of a moderate protein diet. It may be suggested that alkaline potassium, found in fresh fruits and vegetables, may alleviate the hypercalciuria of a North American diet which is typically high in protein | en_US |
| dc.identifier.uri | https://hdl.handle.net/10388/14367 | |
| dc.subject | Chemistry | en_US |
| dc.subject | Chemical technology | en_US |
| dc.subject | Hypercalciuria | en_US |
| dc.title | Effect of adding potassium bicarbonate or sodium bicarbonate on high protein induced hypercalciuria | en_US |
| dc.type.genre | Thesis | en_US |
| thesis.degree.department | Pharmacy and Nutrition | en_US |
| thesis.degree.discipline | Pharmacy | en_US |
| thesis.degree.grantor | University of Saskatchewan | en_US |
| thesis.degree.level | Masters | en_US |
| thesis.degree.name | Master of Science (M.Sc.) | en_US |