Antibacterial and Antiviral Evaluation of Copper Doped Zinc Oxide Coatings for Nosocomial Application
| dc.contributor.advisor | Yang, Dr Qiaoqin | |
| dc.contributor.committeeMember | Chen, Dr Daniel | |
| dc.contributor.committeeMember | Zhang, Dr Chris | |
| dc.contributor.committeeMember | Xiao, Dr Chijin | |
| dc.creator | Chinnasamy, Akshaya | |
| dc.date.accessioned | 2022-08-24T15:38:59Z | |
| dc.date.available | 2022-08-24T15:38:59Z | |
| dc.date.copyright | 2022 | |
| dc.date.created | 2022-08 | |
| dc.date.issued | 2022-08-24 | |
| dc.date.submitted | August 2022 | |
| dc.date.updated | 2022-08-24T15:38:59Z | |
| dc.description.abstract | Infectious micro-organisms such as bacteria and viruses have contributed to nosocomial infections and led to global issues. The application of antimicrobial coatings is an emerging technology to reduce the infections acquired from high-touch surfaces in the hospital. Due to their antimicrobial effects on microbes, metal oxide-based coatings are one of the emerging antimicrobial coatings. Additionally, zinc oxide coatings are one of the coatings that are being considered for biomedical applications due to their potential antimicrobial property. However, there are limited studies on the antibacterial activity of metal-doped Zinc oxide coatings synthesized by reactive sputtering. Moreover, metal Cu gained more importance in hospital surface coating due to its effective antimicrobial property. However, there are few studies on the antibacterial activity of Cu-doped ZnO (Cu-ZnO) coatings and no studies have been done on their antiviral property. In this work, Cu-ZnO coatings were synthesized using the direct current (DC) magnetron sputtering method with different Cu target power between 30W and 75W. The structural characterization of the coatings to confirm the ZnO crystallinity was done using X-ray diffraction (XRD), and the element composition was analyzed using X-ray photoelectron spectroscopy (XPS). The surface morphology was observed using Scanning Electron Microscopy (SEM). The antibacterial evaluation of the coatings was done by disk diffusion and survival assay. The antiviral property of the coatings was evaluated with plaque assay. XRD results show that the coatings have a nanocrystalline wurtzite structure of ZnO with Cu partially substituting Zn to form an interstitial solid solution. SEM images confirm the nanostructure of the coatings and reveal the homogenous distribution of the structure. ZnO coating does not show antibacterial and antiviral activity. However, Cu-ZnO shows inhibition of bacterial growth during the survival assay when PBS used as a medium. Both undoped and Cu-ZnO coating do not show inhibition of the viral growth. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | https://hdl.handle.net/10388/14117 | |
| dc.language.iso | en | |
| dc.subject | Antimicrobial, Sputtering | |
| dc.title | Antibacterial and Antiviral Evaluation of Copper Doped Zinc Oxide Coatings for Nosocomial Application | |
| dc.type | Thesis | |
| dc.type.material | text | |
| thesis.degree.department | Biomedical Engineering | |
| thesis.degree.discipline | Biomedical Engineering | |
| thesis.degree.grantor | University of Saskatchewan | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.Sc.) |