PREVALENCE AND INCIDENCE OF HORMONAL-RELATED CANCERS (HRCs) IN RURAL SASKATCHEWAN: THE SASKATCHEWAN RURAL HEALTH STUDY
Khan, Amal Saleem
MetadataShow full item record
A significant number of rural Canadians dwellers are affected by hormone-related cancers (HRCs) like breast and prostate cancer. Little is known about the rates of occurrence and contextual factors that are associated with the development of breast and prostate cancers in rural residents. This study aimed to determine the incidence and prevalence of breast and prostate cancer among Saskatchewan rural dwellers and to explore individual and contextual factors that are associated with the prevalence of these cancers. To accomplish our goal, we utilized and analyzed data from the Saskatchewan Rural Health Study (SRHS). The SRHS involved a prospective cohort conducted in two phases: the baseline survey (in 2010) and a 4-year follow-up survey (in 2014). In the baseline, the SRHS research team obtained completed questionnaires from 4624 households, including information about 8261 individuals, 18 years and older. Questionnaires were returned from 2797 households comprised of 4867 individuals, in the follow-up survey. Crude prevalence and incidence of HRCs were calculated using appropriate formulae. Adjusted prevalence was calculated using logistic regression based on generalized estimating equations approach to account for hierarchy in the data (individuals within a household). Our study reported the crude prevalence of HRCs (breast and prostate cancers combined) as 3.0%, and 3.4% respectively, at the baseline and follow-up. The adjusted prevalence analysis showed that following variables were significantly associated with HRCs (breast and prostate cancers combined): exposure to radiation (odds ratio [OR] 3.39; 95% confidence interval [CI]: 2.23, 4.84), previous history of cancer in a sibling (i.e. brother or sister) (OR = 1.51, 95% CI: 1.11, 2.07) and a positive history of cancer in father (OR=1.37; 95% CI= 1.01, 1.86). The current study showed cumulative incidence for breast and prostate cancers in rural Saskatchewan as 0.86% and 1.08%, respectively. When combined (i.e. breast and prostate cancers together), the cumulative incidence for HRCs was 0.97%. In summarizing our study findings, HRCs were slightly more prevalent amongst non-farm residents 3.2% when compared with farm residents 2.8% and within the eastern part of the province (6.5%, 6.6%, respectively) as compared to the western part (4.6%, 6.3%, respectively) among both farm and non-farm residents, at the baseline. It appears that the prevalence of HRCs among farm and non-farm rural residents depend on the complex interplay among a variety of factors such as individual and contextual factors.
DegreeMaster of Science (M.Sc.)
DepartmentCommunity Health and Epidemiology
ProgramCommunity and Population Health Science
CommitteeAhmed, Shahid; Engler-Stringer, Rachel; Zaidi, Adnan; Huq, Mobinul
Copyright DateApril 2020
Hormone related cancers, Hormonal-related cancers, HRCs, Breast cancer, Prostate cancer, Crude Prevalence, Adjusted Prevalence, Risk factors, Cumulative Incidence, Rural Saskatchewan, farm and non farm, Saskatchewan rural residents.
Showing items related by title, author, creator and subject.
Stringer, Lorena (2020-09-02)Cancer survival rates are currently lower amongst Indigenous Peoples in Canada than non-Indigenous Peoples in Canada (1). Health professionals speculate that late cancer diagnosis and limited access to screening and support ...
Kickbush, Julie A 1983-; 0000-0002-6955-0479 (2017-04-21)Background: Meticulous rectal cancer surgery is imperative in the treatment of rectal cancer. Total mesorectal excision (TME) is required to decrease local recurrence and improve overall survival after surgical resection ...
Cytotoxic Activity of Sphingosine-1-Phosphate against Human Triple-negative/ Basal-like Breast Cancer Abuhussein, Omar (2016-02-08)Breast cancer is one of the most common malignancy diagnosed in women and is the primary cause of cancer-related deaths in women worldwide. It is a heterogeneous group of diseases that have a different response, prognosis, ...